Results 61 to 70 of about 127,707 (312)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Development of Humanistic Statistics Learning Devices Based one Inquiry and Mind Mapping Models

Al-Jabar, 2018
The purpose of this research are: (1) to determine the characteristic of humanistic statistics learning, (2) to obtain a humanistic statistics learning tools based on valid, practical, and effective inquiry and mind mapping learning model.
Santika Lya Diah Pramesti, Salafudin Salafudin   +1 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

THE EFFECTIVENESS OF INQUIRY BASED LEARNING FOR NATURAL SCIENCE LEARNING IN ELEMENTARY SCHOOL

Journal of Education Technology, 2017
This paper primarily emphasized on describing the use of inquiry in natural science learning at primary school. This study also exposed the validity of inquiry strategy in natural science learning to improve primary schools students’ comprehension ...
Dek Ngurah Laba Laksana
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

The Effect of Open Learning Achievement in Studying Physics Inquiry from the Scientific Working of Students in SMAN 1 Blitar

Jurnal Pendidikan Sains, 2014
Pengaruh Pembelajaran Open Inquiry terhadap Prestasi Belajar Fisika Ditinjau dari Kerja Ilmiah Siswa SMA Negeri 1 Blitar Abstract:  Learning physics are still teacher-centered learning. Students tend to be passive in following the teaching of physics.
Ratnaningtyas Martuti
doaj   +1 more source

META-ANALISIS PENGARUH PENERAPAN MODEL PEMBELAJARAN INKUIRI DALAM HASIL BELAJAR FISIKA SISWA

Jambura Physics Journal, 2020
This research is a meta-analytic study that uses qualitative analysis methods with documentation data collection techniques with pusposive sampling techniques. In 10 journal articles analyzed that the results of 10 research journal articles show that the
Irpan Irpan, Yoga Budi Bhakti
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A case study on based on VR-based inquiry learning: Microcomputer assembly example

Sustainable Futures
The new curriculum standard issued by the Ministry of Education clearly advocates heuristic and inquiry-based teaching. Cultivating students' moral qualities and key abilities of independent inquiry and independent thinking are emphasized.
Liqiao Nong, Nan Gao, Xiaogui Zeng
doaj   +1 more source