Results 51 to 60 of about 4,048,456 (298)

Performance of T-shape barriers with top surface covered with absorptive quadratic residue diffusers [PDF]

, 2008
A previous paper [Applied Acoustics 66 (2005) 709–730] has shown that adding a quadratic residue diffuser (QRD) to the top of a T-shape barrier can provide better barrier performance than an equivalent purely absorptive barrier.
Lam, YW, Monazzam, M
core   +2 more sources

Templated Sequence Insertion Polymorphisms in the Human Genome [PDF]

Frontiers in Chemistry, 2016
Templated Sequence Insertion Polymorphism (TSIP) is a recently described form of polymorphism recognized in the human genome, in which a sequence that is templated from a distant genomic region is inserted into the genome, seemingly at random. TSIPs can be grouped into two classes based on nucleotide sequence features at the insertion junctions; Class ...
Masahiro Onozawa, Masahiro Onozawa, Peter D. Aplan   +2 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Twisted trees and inconsistency of tree estimation when gaps are treated as missing data -- the impact of model mis-specification in distance corrections [PDF]

, 2015
Statistically consistent estimation of phylogenetic trees or gene trees is possible if pairwise sequence dissimilarities can be converted to a set of distances that are proportional to the true evolutionary distances. Susko et al.
Holder, Mark T., McTavish, Emily Jane, Steel, Mike   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Site-specific Photocross-linking Reveals That SecGlp and TRAM Contact Different Regions of a Membrane-inserted Signal Sequence [PDF]

, 1993
A chemically charged amber suppressor tRNA was used to introduce the photoactivatable amino acid (Tmd)Phe at a selected position within the signal sequence of the secretory protein preprolactin.
Andersen, Soren S. L., Ashford, Anthony J., Brunner, Josef, Dobberstein, Bernhard, Giner, Angelika, Görlich, Dirk, Hartmann, Enno, High, Stephen, Martoglio, Bruno, Prehn, Siegfried, Rapoport, Tom A.   +10 more
core   +1 more source

Insertion Pool Sequencing for Insertional Mutant Analysis in Complex Host‐Microbe Interactions [PDF]

Current Protocols in Plant Biology, 2019
AbstractInsertional mutant libraries of microorganisms can be applied in negative depletion screens to decipher gene functions. Because of underrepresentation in colonized tissue, one major bottleneck is analysis of species that colonize hosts. To overcome this, we developed insertion pool sequencing (iPool‐Seq).
Simon Uhse, Florian G. Pflug, Arndt Haeseler, Armin Djamei   +3 more
openaire   +3 more sources

Inference of the impact of insertion sequence (IS) elements on bacterial genome diversification through analysis of small-size structural polymorphisms in Escherichia coli O157 genomes.

Genome Research, 2009
Mobile genetic elements play important roles in the evolution and diversification of bacterial genomes. In enterohemorrhagic Escherichia coli O157, a major factor that affects genomic diversity is prophages, which generate most of the large-size ...
Tadasuke Ooka, Yoshitoshi Ogura, M. Asadulghani, M. Ohnishi, K. Nakayama, J. Terajima, Haruo Watanabe, Tetsuya Hayashi   +7 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Note On The Denisova Cave mtDNA Sequence [PDF]

, 2010
The recently published Altai fossil sequence from Denisova Cave was purported to be so different from anatomically modern humans, yet have the physiological landmarks of that species designation. When the published sequence was examined it was found that
Niccolo Caldararo
core   +1 more source