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Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension. [PDF]
Sci RepZhang SS +29 more
europepmc +1 more source
Update on Physical, Psychological, and Quality of Life Management in Klinefelter Syndrome.
J Clin Endocrinol MetabMehmet B +4 more
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Annals of the New York Academy of Sciences, 2009
Insulin-like factor 3 (INSL3) is produced primarily by testicular Leydig cells and acts by binding to its specific G-protein-coupled receptor, RXFP2 (relaxin family peptide 2). INSL3 is involved in testicular descent during fetal development, and mutations in the INSL3 and RXFP2 genes cause cryptorchidism.
Alberto Ferlin +2 more
exaly +7 more sources
Insulin-like factor 3 (INSL3) is produced primarily by testicular Leydig cells and acts by binding to its specific G-protein-coupled receptor, RXFP2 (relaxin family peptide 2). INSL3 is involved in testicular descent during fetal development, and mutations in the INSL3 and RXFP2 genes cause cryptorchidism.
Alberto Ferlin +2 more
exaly +7 more sources
Characterization of the Rat INSL3 Receptor
Annals of the New York Academy of Sciences, 2005Abstract: Human LGR8, initially discovered as a low‐affinity relaxin receptor, has now been characterized as the INSL3 receptor. To investigate LGR8 function in the rat, an LGR8 ortholog was identified in the rat genome, and the full‐length sequence was cloned and expressed. Rat LGR8 bound INSL3 with high affinity, clearly demonstrating that it is the
Daniel J Scott
exaly +3 more sources
Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy [PDF]
Journal of Clinical Laboratory Analysis, 2021 AbstractBackgroundInsulin‐like factor 3 (INSL3) was stated to be an essential regulator in many diseases. This present study aimed to explore the underlying mechanisms of INSL3 in diabetic nephropathy (DN).MethodsThe serum samples were obtained from 121 DN patients, 67 T2DM patients, and 44 healthy controls. Twenty SD rats were used to establish the DN
Jing Zhu
exaly +3 more sources
INSL3 has tumor‐promoting activity in thyroid cancer [PDF]
International Journal of Cancer, 2010 AbstractThe functional role of INSL3 and its receptor RXFP2 in carcinogenesis is largely unknown. We have previously demonstrated (pro‐)cathepsin‐L as a target of INSL3 in human thyroid cancer cells facilitating penetration of tumor cells through elastin matrices.
Sabine Hombach-Klonisch +2 more
exaly +3 more sources
INSL3 in the muscolo-skeletal system
Molecular and Cellular Endocrinology, 2019Bone and skeletal muscle are currently considered a unified functional unit, showing complementary regulation at mechanical, biochemical, paracrine and metabolic levels. This functional unit undergoes a central hormonal regulation which is mainly ascribed to sex steroids and, in particular, androgens.
De Toni, Luca +4 more
openaire +2 more sources