Results 171 to 180 of about 4,038 (203)
INSL3/RXFP2 Signaling in Testicular Descent [PDF]
Annals of the New York Academy of Sciences, 2009 Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14.5 and markedly increased after birth in the developing cremaster muscle, as well as in the epididymis and testicular Leydig and germ cells ...
Alberto Ferlin +2 more
exaly +7 more sources
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Cryptorchidism in mice mutant for Insl3
Nature Genetics, 1999Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours. Testicular descent from abdomen to scrotum occurs in two distinct phases: the trans-abdominal phase and the inguino ...
S, Nef, L F, Parada
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Annals of the New York Academy of Sciences, 2009
The use of radioisotope‐labeled peptides and proteins in bioassays is diminishing as a consequence of the emergence of fluorescent lanthanide‐labeled probes. We describe a simple, single‐step labeling of synthetic human insulin‐like peptide 3 (INSL3) with a commercially available activated europium chelator.
Fazel, Shabanpoor +4 more
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The use of radioisotope‐labeled peptides and proteins in bioassays is diminishing as a consequence of the emergence of fluorescent lanthanide‐labeled probes. We describe a simple, single‐step labeling of synthetic human insulin‐like peptide 3 (INSL3) with a commercially available activated europium chelator.
Fazel, Shabanpoor +4 more
openaire +2 more sources
FEBS Journal, 2009
Insulin‐like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfamily of peptide hormones. One of its primary functions is to initiate and mediate descent of the testes of the male fetus via interaction with its G protein‐coupled receptor, RXFP2.
Xiao Luo, John D Wade, Zhan-Yun Guo
exaly +3 more sources
Insulin‐like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfamily of peptide hormones. One of its primary functions is to initiate and mediate descent of the testes of the male fetus via interaction with its G protein‐coupled receptor, RXFP2.
Xiao Luo, John D Wade, Zhan-Yun Guo
exaly +3 more sources
Mechanisms of INSL3 signaling in male reproductive organs
Italian Journal of Anatomy and Embryology, 2014Global ablation of INSL3 hormone or its receptor RXFP2 in male mice results in cryptorchidism and infertility. Using novel LacZ knock-in Rxfp2 allele we demonstrated a strong expression of this gene in postmeiotic germ cells. RXFP2 was expressed in embryonic and neonatal gubernaculum. No RXFP2 expression was detected in cremaster muscles in adult mice.
Huang, Zaohua +3 more
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Genetic Targeting of Relaxin and Insl3 Signaling in Mice
Annals of the New York Academy of Sciences, 2005Abstract: We studied ligand‐receptor interactions between relaxin (RLN), insulin‐like 3 peptide (INSL3), and LGR7 and LGR8 receptors. The phenotypic effects of deficiency for Lgr7 and Lgr8 receptors, transgenic overexpression of Rln1 and Insl3, and different combinations of these mutations in mice were analyzed.
Shu, Feng +3 more
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Chemical synthesis and biological activity of rat INSL3
Journal of Peptide Science, 2001AbstractThe recently identified protein, insulin 3 (INSL3), has structural features that make it a bona fide member of the insulin superfamily. Its predicted amino acid sequence contains the classic two‐peptide chain (A‐ and B‐) structure with conserved cysteine residues that results in a disulphide bond disposition identical to that of insulin ...
K J, Smith +8 more
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The role of the testicular factor INSL3 in establishing the gonadal position
Molecular and Cellular Endocrinology, 2000 INSL3, also designated Leydig insulin-like (Ley I-L) or relaxin-like factor (RLF), belongs to the insulin-like hormone superfamily. It is expressed in pre- and postnatal Leydig cells of the testis and in postnatal theca cells of the ovary. This sexual dimorphic pattern of INSL3 expression during development led us to suggest that the INSL3 factor could
Adham, Ibrahim M. +2 more
exaly +5 more sources
The “Hot Wires” of the Relaxin‐Like Factor (Insl3)
Annals of the New York Academy of Sciences, 2009The discovery of the total separation of receptor‐binding and signal‐generating regions of the relaxin‐like factor (RLF) has provided an opportunity to investigate the mechanism of transmembrane signaling. The receptor‐binding residues of RLF are in the B chain of the two‐chain molecule and extend from the midregion of the central helix to the ...
Christian, Schwabe, Erika E, Büllesbach
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Constitutive regulation of the Insl3 gene in rat Leydig cells
Molecular and Cellular Endocrinology, 2005Insulin-like factor 3 (Insl3) is a major new product of the Leydig cells in all mammalian species so far examined. The rat Insl3 gene is encoded by two exons in close juxtaposition to the Jak3 gene. Using RT-PCR analysis we now show that in the rat testis it is expressed as both major and minor splice variants, the former encoding the normal protein ...
Sadeghian, Helen +4 more
openaire +5 more sources