Results 121 to 130 of about 313,273 (308)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Competency Education Series: Policy Brief One, An Emerging Federal Role for Competency Education [PDF]
, 2013 After two decades of standards-based reform, a new education paradigm has begun to take hold -- the rise of competency education. This new vision builds on the strong foundation of new college and career ready standards, challenging stakeholders to ...
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
國小線上圖書資訊素養教材之設計與發展-以「書精靈王國」為例 The Design and Development of Online Courseware for Library Instruction and Information Literacy-Use Book Kingdom for Example [PDF]
Jiàoyù zīliào yǔ túshūguǎn xué, 2005 九年一貫的課程綱要宣布後，學習已不再侷限於教室裡的講課，學生必須拓展自己的觸角接觸外界資訊爆炸景況，而資料來源的蒐集整理也不再以圖書館為最大宗， 網路上的資訊更加豐富，但有良莠不齊的問題存在。未來人才的競爭基本能力是在資訊大海中能找到自己所需的資訊。就目前的國小學科教育來看，這方面能力的培 養似乎較為缺乏，因此研究者根據這樣的需求與天母國小圖書館合作設計一套適合國小三~六年級的線上圖書資訊素養教材系統，讓教師於教學時輔助使用，學生亦 可不受時空限制進行自學或課後複習。教材系統將依循教學系統設計進行分析 ...
Chin-Fang Chen +2 more
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Providing Instruction Based on Students' Learning Style Preferences Does Not Improve Learning. [PDF]
Front Psychol, 2020 Rogowsky BA, Calhoun BM, Tallal P.
europepmc +1 more source
EditEval: An Instruction-Based Benchmark for Text Improvements
Proceedings of the 28th Conference on Computational Natural Language LearningEvaluation of text generation to date has primarily focused on content created sequentially, rather than improvements on a piece of text. Writing, however, is naturally an iterative and incremental process that requires expertise in different modular skills such as fixing outdated information or making the style more consistent.
Jane Dwivedi-Yu +8 more
openaire +2 more sources
Using academic notebooks to support achievement and promote positive environments in differentiated classrooms [PDF]
, 2013 Authors Examine How the Use of Academic Notebooks Impacts Collaborative Learning Experiences of Young ...
LeClair, Caitlin +3 more
core +1 more source