Results 21 to 30 of about 286,304 (210)

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]

, 2014
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M., Robb, Ellen L., Selman, Colin, Sinclair, Amy, Stuart, Jeffrey A., Withers, Dominic J.   +5 more
core   +1 more source

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]

, 2018
Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan, Farias-Eisner, Gina, Farias-Eisner, Robin, Fogelman, Alan M, Gao, Feng, Grijalva, Victor, Nwokedi, Josephine, Reddy, Srinivasa T, Su, Feng, Trost, Hannah, Yalamanchi, Ashna, Yalamanchi, Meghna   +11 more
core   +3 more sources

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation [PDF]

, 2016
Experimental results for the determination of internalization rates for IGF1-IGF1R, IGF2-IGF1R, IGF2-IGF2R.
Dan Tian, Isaiah Mitchell, Pamela K. Kreeger   +2 more
core   +5 more sources

DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling [PDF]

, 2020
DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and ...
Braeckman, Bart, Zečić, Aleksandra
core   +1 more source

Meta‐analysis of peripheral insulin‐like growth factor 1 levels in schizophrenia

Brain and Behavior, 2023
Objective We aimed to investigate if there is a significant difference in peripheral insulin‐like growth factor 1 (IGF‐1) levels between schizophrenia patients and healthy controls and to determine whether a difference exists before and after initiation ...
Ana V. Pejcic, Slobodan M. Jankovic, Vladimir Janjic, Milan Djordjic, Jovana Z. Milosavljevic, Milos N. Milosavljevic   +5 more
doaj   +1 more source

Elevated intraocular pressure in patients with acromegaly [PDF]

, 2014
To evaluate central corneal thickness (CCT) and intraocular pressure (IOP) in a cohort of acromegalic patients, and to correlate CCT with serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1)
Floriani, Irene, Giustina, Andrea, Katsanos, Andreas, Konstas, Anastasios, Mazziotti, Gherardo, Porcelli, Teresa, Quaranta, Luciano, Riva, Ivano   +7 more
core   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin [PDF]

Endocrinology and Metabolism
This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important.
Eline C. Nijenhuis-Noort, Kirsten A. Berk, Sebastian J. C. M. M. Neggers, Aart J. van der Lely   +3 more
doaj   +1 more source

Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]

, 2009
Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Hembree JR, Huynh H, Munetoshi Kanayama, Ohtsuki T, Ohtsuki T, Pierro E, Sakae Takeuchi, Shiraga M, Sumio Takahashi, Takaoka M, Tetsuya Maekawa   +10 more
core   +1 more source