Results 311 to 320 of about 635,202 (354)

Growth Hormone and Insulin-Like Growth Factor-1

2016
Human growth hormone (GH) was first isolated from the human pituitary gland in 1945 and found to promote the growth of children with hypopituitarism. Since the formation of the World Anti-Doping Association, human GH has appeared on the list of forbidden substances.
Nicholls, A.R., Holt, Richard
openaire   +3 more sources

Insulin-Like Growth Factor 1 Expression in Thyroid Tumors

Applied Immunohistochemistry & Molecular Morphology, 2000
Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunoreactivity in normal and neoplastic thyroids (50 ...
Maiorano E, Ciampolillo A, Viale G, Maisonneuve P, Ambrosi A, Triggiani V, Marra E, Perlino E   +7 more
openaire   +4 more sources

Serum Levels of Insulin-like Growth Factor-1 and Insulin-like Growth Factor-1 Binding Proteins After Radical Prostatectomy

Journal of Urology, 2002
Elevated serum levels of insulin-like growth factor-1 (IGF-1) have been consistently shown to be a risk factor for prostate cancer. Alterations in serum IGF-1 binding proteins 1 to 3 have also been associated with prostate cancer risk. A potentially important complication in these studies is that prostate tissue, perhaps especially malignant prostate ...
Glenn J, Bubley, Steve P, Balk, Meredith M, Regan, Stephen, Duggan, Mary Ellen, Morrissey, William C, Dewolf, Ellena, Salgami, Christos, Mantzoros   +7 more
openaire   +2 more sources

Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone

Cellular Immunology, 2005
Almost all of the previous studies with growth hormone (GH) have been done with exogenously supplied GH and, therefore, involve actions of the hormone through its receptor. However, the actions of endogenous or lymphocyte GH are still unclear. In a previous study, we showed that overexpression of GH (GHo) in a lymphoid cell line resulted in protection ...
Douglas A, Weigent, Robyn E, Arnold
openaire   +2 more sources

Insulin-like Growth Factor-1 Deficiency

2019
Since insulin-like growth factor-1 (IGF-1) measurement has become widely known to reflect cumulative growth hormone (GH) secretion, it is not surprising for clinicians to be tempted to use IGF-1 levels to not only screen for GH excess but for GH deficiency also (Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center.
Thomas Ittoop, S. Sethu K. Reddy
openaire   +1 more source

Insulin-like growth factor-1 expression in reflux nephropathy

Pediatric Surgery International, 2004
Reflux nephropathy (RN) is recognised as a major cause of end-stage renal failure in children and young adults. Insulin-like growth factor-1 (IGF-1), a peptide growth factor produced by collecting ducts, and its receptor, insulin-like growth factor-1 receptor (IGF-1R), are present in the glomeruli and basolateral membrane of renal proximal tubular ...
Boris, Chertin, Amicur, Farkas, Prem, Puri   +2 more
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Targeting insulin-like growth factor 1 receptor in sarcomas

Current Opinion in Oncology, 2008
The present review examines the rationale for targeting insulin-like growth factor-I receptor in sarcoma therapy and highlights some key issues that need to be addressed as clinical trials targeting insulin-like growth factor-I receptor proceed.Preclinical evidence supports proof of principle for targeting insulin-like growth factor-I receptor ...
Katia, Scotlandi, Piero, Picci
openaire   +2 more sources