Results 171 to 180 of about 34,204,101 (306)

Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity: Entrainment of Metabolic and Brain Functions. [PDF]

Cells
García-Magro N, Mesa-Lombardo A, Nuñez Á.   +2 more
europepmc   +1 more source

Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons. [PDF]

Int J Mol Sci, 2022
Pignatelli J, de Sevilla MEF, Sperber J, Horrillo D, Medina-Gomez G, Aleman IT.   +5 more
europepmc   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Mediating effect of osteocalcin underlying the link between insulin-like growth factor-I and gestational diabetes mellitus. [PDF]

BMC Pregnancy Childbirth
Cui L, Gao Y, Sun R, Li Z, Zhang Z, Ji L, Wang Y, Ye H, Qin L.   +8 more
europepmc   +1 more source

Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis. [PDF]

Eur J Nutr, 2023
Watling CZ, Kelly RK, Tong TYN, Piernas C, Watts EL, Tin Tin S, Knuppel A, Schmidt JA, Travis RC, Key TJ, Perez-Cornago A.   +10 more
europepmc   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Clinical biochemical evaluation of trace elements and insulin-like growth factor-I in children with short stature: Diagnostic and correlative insights from the Guangzhou cohort. [PDF]

J Med Biochem
Huang B, Wang X, Zhang Y.
europepmc   +1 more source

Insulin-like growth factor-I on skeletal muscle growth and repair of research progress

, 2006
The growth hormone (GH)/insulin- like growth factor- I (IGF- I) axis is one of the most important regulators of skeletal muscle growth. Insulin- like growth factor- I is expressed in many tissues, however it may have different functions.
Huang, Liping, Zhou, Shi, Cao, Longjun
core  

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017). [PDF]

Animals (Basel)
Davis ME, Simmen RCM.
europepmc   +1 more source