Results 191 to 200 of about 34,204,101 (306)

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. [PDF]

Front Endocrinol (Lausanne)
Yuen KCJ, Hjortebjerg R, Ganeshalingam AA, Clemmons DR, Frystyk J.   +4 more
europepmc   +1 more source

Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons. [PDF]

Mol Psychiatry, 2022
Fernández de Sevilla ME, Pignatelli J, Zegarra-Valdivia JA, Mendez P, Nuñez A, Torres Alemán I.   +5 more
europepmc   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Correction: Nishikawa et al. Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway. <i>Biomedicines</i> 2025, <i>13</i>, 566. [PDF]

Biomedicines
Nishikawa T, Ohtomo N, Inoue Y, Takahashi M, Ikeda H, Koike K, Yamamichi N, Fujishiro M, Tomiya T.   +8 more
europepmc   +1 more source

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. [PDF]

Structure, 2022
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC.   +8 more
europepmc   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Hepatic Expression of Growth Hormone Receptor (<i>GHrec</i>) and Insulin-like Growth Factor-I (<i>IGF-I</i>) Genes and Cellular Location of <i>IGF-I</i> mRNA in Diploid and Triploid Atlantic Salmon (<i>Salmo salar</i>) Undergoing Parr-Smolt Transformation. [PDF]

Animals (Basel)
Bortoletti M, Fonsatti E, Maccatrozzo L, Peruzzi S, Jobling M, Vascellari M, Radaelli G, Bertotto D.   +7 more
europepmc   +1 more source

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. [PDF]

Front Aging Neurosci, 2021
Zegarra-Valdivia JA, Chaves-Coira I, Fernandez de Sevilla ME, Martinez-Rachadell L, Esparza J, Torres-Aleman I, Nuñez A.   +6 more
europepmc   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source