Results 261 to 270 of about 34,204,101 (306)

Clinical Uses of Insulin-like Growth Factor I

Annals of Internal Medicine, 1994
Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions. The therapeutic potential of recombinant human IGF-I treatment is being investigated in various growth hormone-resistant and insulin-resistant disorders. Recent studies have shown that IGF-I may substitute for growth hormone in promoting linear
C A, Bondy, L E, Underwood, D R, Clemmons, H P, Guler, M A, Bach, M, Skarulis   +5 more
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Insulin-like growth factor-I: Clinical studies

Drugs of Today, 1998
Insulin-like growth factor-I (IGF-I) has endocrine, autocrine and paracrine properties. Receptors for IGF-I are present on virtually all cell types but are located mainly on cells of mesenchymal origin, such as fibroblasts, chondrocytes and osteoblasts. Growth hormone (GH)-dependent and GH-independent actions of IGF-I have been implicated in normal and
P E, Vos, H P, Koppeschaar, W R, de Vries, J H, Wokke   +3 more
openaire   +2 more sources

Drug delivery of Insulin-like growth factor I

European Journal of Pharmaceutics and Biopharmaceutics, 2015
This review starts off outlining the control of Insulin-like growth factor I (IGF-I) kinetics in Nature and by virtue of a complex system of 6 binding proteins controlling half-life and tissue distribution of this strong anabolic peptide. In addition, alternative splicing is known to result in IGF-I variants with modulated properties in vivo and this ...
Isabel Schultz, Joel Wurzel, Lorenz Meinel   +2 more
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Defining Insulin-Like Growth Factor-I Deficiency

Hormone Research, 2006
• The GH-IGF system should be viewed like other endocrine systems, with a central, trophic hormone (GH) and a peripherally active hormone (IGF-I). • A decrease in IGF-I production, without a concomitant impairment in GH secretion, should be termed 'Primary IGF deficiency'.
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The insulin-like growth factor-I receptor as an oncogene

Archives of Physiology and Biochemistry, 2009
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic, cell-survival, and transforming activities. IGF-IR expression is a fundamental prerequisite for the acquisition of a malignant phenotype, as suggested by ...
Haim, Werner, Ilan, Bruchim
openaire   +2 more sources

Nutritional regulation of insulin-like growth factor-I

Metabolism, 1995
Several lines of evidence indicate that in the human, insulin-like growth factor-I (IGF-I) is nutritionally regulated. Both energy and protein availability are required for maintenance of IGF-I. Measurements of serum IGF-I constitute a sensitive means for monitoring the response of acutely ill patients to nutritional intervention.
Ketelslegers, Jean-Marie, Maiter, Dominique, Maes, Marc, Underwood, L E, Thissen, Jean-Paul   +4 more
openaire   +2 more sources

Insulin-like growth factor-I and cancer risk

Growth Hormone & IGF Research, 2004
Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on ...
Yasir H, Ibrahim, Douglas, Yee
openaire   +2 more sources

Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland

Journal of Dairy Research, 1999
The mammary gland is an example of a tissue of epidermal origin that depends for the development of its characteristic morphology on underlying mesenchymal cells. The interaction between mesenchyme and epithelium appears to be mediated by polypetide growth factors.
Forsyth, Isabel A., Gabai, Gianfranco, Morgan, Geoff   +2 more
openaire   +4 more sources

Growth hormone, insulin‐like growth factor I, and motoneuron size

Journal of Neurobiology, 1997
In this study we asked whether growth hormone (GH) and one of its key mediators, insulin-like growth factor I (IGF-I), influence spinal motoneuron size in conjunction with whole body size. We present evidence that GH has such a role, possibly without the mediation of IGF-I.
L, Chen, P K, Lund, S B, Burgess, B E, Rudisch, D L, McIlwain   +4 more
openaire   +2 more sources

Regulation of Insulin-Like Growth Factor-I by Nutrition

2004
Nutrition is one of the principal regulators of circulating IGF-I. Many mechanisms are involved in the nutritional regulation of IGF-I. Both energy and protein are critical to the regulation of serum IGF-I concentrations. After fasting, adequate energy and protein are necessary for restoration of serum IGF-I, but energy may be somewhat more ...
Thissen, Jean-Paul, Beauloye, Véronique, Ketelslegers, Jean-Marie, Underwood, Louis E.   +3 more
openaire   +2 more sources