Results 151 to 160 of about 408,308 (200)

Immunoreactive insulin-like growth factor II in urine

Acta Endocrinologica, 1990
Abstract. Insulin-like growth factor II and insulin-like growth factor binding protein-1 were identified and quantified in the urine of 23 healthy subjects between 17 and 76 years of age. IGF-II was measured after separation by gel chromatography at low pH and compared with IGF-I levels in the same samples, whereas IGF binding protein-1 was measured in
W, Zumkeller, K, Hall
openaire   +2 more sources

Chemical synthesis of insulin‐like growth factor II

International Journal of Peptide and Protein Research, 1985
Human insulin‐like growth factor II (IGF‐II) with 67 amino acids and three disulfide bridges has been synthesized by the solid‐phase method. The synthetic hormone is shown to be homogeneous in high performance liquid chromatography (HPLC), high performance partition chromatography (HPPC), and chromatofocusing.
D, Yamashiro, C H, Li
openaire   +2 more sources

Variable accumulation of insulin-like growth factor II in mouse tissues deficient in insulin-like growth factor II receptor

The International Journal of Biochemistry & Cell Biology, 1999
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
C M, Nolan, M A, Lawlor
openaire   +2 more sources

Identification of receptors for insulin-like growth factor II in two insulin-like growth factor II producing cell lines

Biochemical and Biophysical Research Communications, 1986
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
P D, Lee, D, Hodges, R L, Hintz, J H, Wyche, R G, Rosenfeld   +4 more
openaire   +2 more sources

Secretion of insulin-like growth factor II into milk

Biochemical and Biophysical Research Communications, 1992
125I-labeled insulin-like growth factor II (IGF-II) was infused directly into the pudic artery supplying one gland of lactating goats (n = 4). Maximum specific activity for [125I]IGF-II transferred into milk from the infused gland was reached 60 min after that in plasma and was 2.5 fold greater than in milk from the non-infused gland.
C G, Prosser, I R, Fleet
openaire   +2 more sources

Insulin-like growth factor II induces apoptosis in osteoblasts

Bone, 2004
The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine orange-ethidium bromide staining.
Gloria A, Gronowicz, Mary-Beth, McCarthy, Hai, Zhang, Wenjian, Zhang   +3 more
openaire   +2 more sources

Insulin-Like Growth Factor-II Receptors

1990
In the past few years there has been an explosive increase in interest in peptides of the insulin-like growth factor (IGF) family. This follows a period of over two decades, dating back to the discovery of “somatomedins,” as the IGFs were originally known, in the late 1950s.
Robert C. Baxter, Carolyn D. Scott
openaire   +1 more source

Insulin-like growth factor II and nonsuppressible insulin-like activity levels in newborns

American Journal of Obstetrics and Gynecology, 1990
We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. Our results obtained by use of one-way analysis of variance showed that the insulin-like growth factor II and ...
N A, Samaan, P N, Schultz, F K, Pham
openaire   +2 more sources

Insulin-Like Growth Factor-II: Possible Local Growth Factor in Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1990
Pheochromocytomas, neural crest tumors, express an abundance of insulin-like growth factor-II (IGF-II). To assess further the potential for IGF-II to play an autocrine role for these tumors, we measured 1) IGF-II content by RRA in 7 pheochromocytomas and peripheral blood in these patients, 2) IGF-II receptors by Western analysis, and 3) characterized ...
M C, Gelato, J, Vassalotti
openaire   +2 more sources

Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells

Journal of Cellular Physiology, 2000
The soluble form of the insulin-like growth factor II (IGF-II)/mannose 6-P (IGF-II/M6P) receptor is released by cells in culture and circulates in the serum. It retains its ability to bind IGF-II and blocks IGF-II-stimulated DNA synthesis in isolated rat hepatocytes.
C D, Scott, J, Weiss
openaire   +2 more sources