Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]
, 2012 Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
David Epstein +9 more
core +8 more sources
Late recurrence of a malignant hypoglycemia‑inducing pelvic solitary fibrous tumor secreting high‑molecular‑weight insulin‑like growth factor‑II: A case report with protein analysis [PDF]
, 2016 The present study reports a case of recurrent malignant pelvic solitary fibrous tumor (SFT) that induced non-islet cell tumor hypoglycemia via high-molecular-weight insulin-like growth factor-II in a 72-year-old male patient. The tumor recurred ~12 years
FUKUDA Izumi +8 more
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Changes in cardiac phenotype in hypertrophy and failure: From receptor to gene [PDF]
, 1997 The terminally differentiated adult cardiac myocyte cannot undergo cellular division. Growth of the heart in response to chronic hemodynamic overload therefore occurs through hypertrophy of the myocytes.
Heugten, H.A. (Han) van +1 more
core +3 more sources
A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease. [PDF]
PLoS ONE, 2015 Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to ...
Eirini Kalliolia +10 more
doaj +1 more source
The matricellular functions of small leucine-rich proteoglycans (SLRPs) [PDF]
, 2009 The small leucine-rich proteoglycans (SLRPs) are biologically active components of the extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs covalently linked to glycosaminoglycan (GAG) side chains.
Rosetta Merline +2 more
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Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability [PDF]
Biochemical Journal, 1996 Insulin-like growth factor II (IGF-II) is synthesized in many tissues, but the main site of production is the liver. In this paper we show that IGF-II mRNA levels are dependent on the growth conditions of the cells. In Hep3B cells, serum deprivation leads to a marked increase in IGF-II mRNA levels.
Scheper, W. +2 more
openaire +3 more sources
Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta
Obstetrics and Gynecology International, 2010 Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta.
Yan-Min Luo +5 more
doaj +1 more source
Case Reports in Oncology, 2012 An 83-year-old man underwent complete resection of a large malignant solitary fibrous tumor in the retroperitoneum in 2006 and of a local recurrent tumor in 2010. In 2011, he was admitted to our hospital because of hypoglycemia.
Tatsuo Hata +3 more
doaj +1 more source
Annals of Internal Medicine: Clinical Cases, 2022 A 60-year-old man with a history of metastatic intracranial hemangiopericytoma and type 2 diabetes mellitus presented with acute episodes of confusion and dizziness.
Natnicha Leelaviwat +4 more
doaj +1 more source
Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain - An acidic cluster containing a key aspartate is important for function in lysosomal enzyme sorting [PDF]
, 1997 We have used systematic mutational analysis to identify signals in the 166-residue murine cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain required for efficient sorting of lysosomal enzymes.
Chen, Hong Jung +2 more
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