Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations. [PDF]
PLoS ONE, 2016 The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin.
Anastasios Papaioannou +2 more
doaj +1 more source
The IGF system during growth and differentiation of the mouse [PDF]
, 1999 The insulin-like growth factors (IGFs) were first discovered in 1957 by Salmon and Daughaday (1957). They found that in vivo administration of growth hormone (GH) induced a serum factor capable of stimulating sulfate uptake in cartilage.
Kleffens, M. (Marjolein) van
core +1 more source
Role of sox9 in growth factor regulation of articular chondrocytes [PDF]
, 2015 Chondrogenic polypeptide growth factors influence articular chondrocyte functions that are required for articular cartilage repair. Sox9 is a transcription factor that regulates chondrogenesis, but its role in the growth factor regulation of chondrocyte ...
Acton, Anthony J. +4 more
core +1 more source
SHIP2: A ‘‘NEW’’ Insulin Pathway Target for Aging Research [PDF]
, 2014 Strong evidence suggests that systemic inflammation and central adiposity contribute to and perpetuate metabolic syndrome. All of these alterations predispose individuals to type 2 diabetes mellitus (T2DM), cardiovascular disease, as well as Alzheimer ...
ACCARDI, Giulia +10 more
core +1 more source
Genetics Selection Evolution, 2005 The genes that are part of the somatotropic axis play a crucial role in the regulation of growth and development of chickens. The identification of genetic polymorphisms in these genes will enable the scientist to evaluate the biological relevance of ...
Yang Guanfu +5 more
doaj +1 more source
Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study [PDF]
, 2010 INTRODUCTION: Non-excitable muscle membrane indicates critical illness myopathy (CIM) during early critical illness. We investigated predisposing risk factors for non-excitable muscle membrane at onset of critical illness.
Claudia D Spies +8 more
core +3 more sources
Insulin-like growth factor II stimulates motor nerve regeneration. [PDF]
Proceedings of the National Academy of Sciences, 1992 Injury to mammalian motor nerves can lead to paralysis, but relatively successful regeneration may occur when conditions are favorable. Elucidation of the mechanism upholding successful regeneration is of theoretical and clinical interest. In this study, the hypothesis that insulin-like growth factor II (IGF-II) can stimulate motor nerve regeneration ...
S L, Near +3 more
openaire +2 more sources
The Involvement of the GH/IGF-I Axis in Cognitive Functions of Adult Patients and Healthy Subjects [PDF]
, 2012 We describe the synthesis and purification of two functional peptides, namely human insulin-like growth factor II (IGF-II) and Xenopus laevis magainin II in Hansenula polymorpha after their synthesis as hybrid proteins fused to the C terminus of ...
Deijen, J.B., Drent, M.L., Driel, M.I.
core +7 more sources
Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]
, 1995 Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter +3 more
core +1 more source
Recurrent Meningeal Hemangiopericytoma with Multiple Metastasis and Hypoglycemia: A Case Report
Case Reports in Medicine, 2012 Aims. We report on the unusual case of a 43-year-old man who developed recurrent meningeal hemangiopericytoma and presented with hypoglycemia 6 years after excision of the tumor. Methods and Results.
Jammy Kin Iong Chan +3 more
doaj +1 more source