Results 171 to 180 of about 830,008 (409)

Age-related loss of skeletal muscle function; impairment of gene expression. [PDF]

, 2004
Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation.
Goldspink, G
core  

The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population

, 1969
Yunkai Li, Hui Wang, Xinwei Zhu, Guo Liang, Zuo Jin-liang   +4 more
openalex   +1 more source

The Fetal Rat Binding Protein for Insulin-Like Growth Factors is Expressed in the Choroid Plexus and Cerebrospinal Fluid of Adult Rats [PDF]

, 1989
Lucy Y.-H. Tseng, Alexandra L. Brown, Yvonne W.-H. Yang, Joyce A. Romanus, Craig C. Orlowski, Terry Taylor, Matthew M. Rechler   +6 more
openalex   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Activation of the insulin receptor by insulin-like growth factor 2

Nature Communications
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function.
Weidong An, Catherine Hall, Jie Li, Albert Hung, Jiayi Wu, Junhee Park, Liwei Wang, Xiao-chen Bai, Eunhee Choi   +8 more
doaj   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Evidence that Receptor Aggregation may Play a Role in Transmembrane Signaling through the Insulin-Like Growth Factor-I Receptor [PDF]

, 1988
Nobuhiko Ikari, Hiroko Yoshino, Alan C. Moses, Jeffrey S. Flier   +3 more
openalex   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Insulin and Insulin-like Growth Factor signalling (IGF) pathways and cancer / Wan Iryani Wan Ismail, Mohd Nazri Abu, Muhammad Ashraf Mohd Salleh, Izmil Haikal Zainol and Rosmadi Mohd Yusoff [PDF]

, 1992
Cell signalling is part of a strategy in drug discovery. Among the focus is by studying the insulin and insulin-like growth factor (IGF1R) signalling pathways. The molecular mechanism of insulin and IGF1R signalling pathways have been studied extensively.
Abu, Mohd Nazri, Mohd Salleh, Muhammad Ashraf, Zainol, Izmil Haikal, Mohd Yusoff, Rosmadi   +3 more
core  

Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells [PDF]

, 1988
Karen Huff, Cornelius Knabbe, Ralph K. Lindsey, Dwight Kaufman, Diane Bronzed, Marc E. Lippman, Robert B. Dickson   +6 more
openalex   +1 more source