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Insulin-like growth factors in poultry
Domestic Animal Endocrinology, 1997A large amount of research, primarily in mammals, has defined to a great extent the pleiotropic effects of the IGF system on growth, development, and intermediary metabolism. Similar elucidations in poultry were hindered to some extent by the absence of native peptides (IGF-I and IGF-II) until their purification, followed by the production of ...
J P, McMurtry, G L, Francis, Z, Upton
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Insulin-Like Growth Factors, Nutrition and Growth
2013Nutritional status is a key factor in the regulation of human linear growth. The growth hormone (GH)-IGF axis consists of a cascade of finely tuned molecular mechanisms which are vulnerable to protein-calorie deficiency. The most notable evidence for this is the presence of IGF-1 deficiency, that can be caused by failure of a number of processes ...
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Insulin-like growth factors and neoplasia
Nature Reviews Cancer, 2004The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating cellular proliferation and apoptosis. Converging results from epidemiological research and in vivo carcinogenesis models indicate that high levels of circulating IGF1 are associated with increased risk of several common cancers.
Michael N, Pollak +2 more
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Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I
American Journal of Physiology-Renal Physiology, 1991We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid ...
S, Kobayashi +2 more
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The Phylogeny of the Insulin-like Growth Factors
1998The insulin-like growth factors are major regulators of growth and development in mammals and their presence in lower vertebrates suggests that they played a similarly fundamental role throughout vertebrate evolution. While originally perceived simply as mediators of growth hormone, on-going research in mammals has revealed several hierarchical layers ...
Reinecke M, Collet C
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Biology of insulin‐like growth factors in development
Birth Defects Research Part C: Embryo Today: Reviews, 2003AbstractInsulin‐like growth factors (IGFs) provide essential signals for the control of embryonic and postnatal development in vertebrate species. In mammals, IGFs act through and are regulated by a system of receptors, binding proteins, and related proteases. In each of the many tissues dependent on this family of growth factors, this system generates
Dupont, Joëlle, Holzenberger, M.
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The Somatomedins: Insulin-Like Growth Factors
1986Publisher Summary This chapter presents an account of the recent advances in the understanding of the origins, functions, and clinical significance of insulin-like growth factors. The term “somatomedin” was coined over a decade ago to describe partly characterized plasma factors that (1) stimulated sulfate incorporation into chondroitin sulfate of ...
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The Insulin-like Growth Factors
QJM: An International Journal of Medicine, 1992Abstract The past decade has seen an explosion in our understanding of the factors regulating cell proliferation and differentiation. One of the most exciting advances has been the recognition of the pivotal role of the peptide growth factors in these processes.
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1990
Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
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Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday 1957).
M. M. Rechler, S. P. Nissley
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