Results 261 to 270 of about 13,071,502 (301)
Some of the next articles are maybe not open access.
Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I
American Journal of Physiology-Renal Physiology, 1991We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid ...
S, Kobayashi +2 more
openaire +2 more sources
Biology of insulin‐like growth factors in development
Birth Defects Research Part C: Embryo Today: Reviews, 2003AbstractInsulin‐like growth factors (IGFs) provide essential signals for the control of embryonic and postnatal development in vertebrate species. In mammals, IGFs act through and are regulated by a system of receptors, binding proteins, and related proteases. In each of the many tissues dependent on this family of growth factors, this system generates
Dupont, Joëlle, Holzenberger, M.
openaire +3 more sources
The Somatomedins: Insulin-Like Growth Factors
1986Publisher Summary This chapter presents an account of the recent advances in the understanding of the origins, functions, and clinical significance of insulin-like growth factors. The term “somatomedin” was coined over a decade ago to describe partly characterized plasma factors that (1) stimulated sulfate incorporation into chondroitin sulfate of ...
openaire +2 more sources
Downstream Insulin-Like Growth Factor
2012Until 10 years ago genetic defects that cause a child to be born small for gestational age (SGA) were poorly defined. With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a ...
Roland, Pfäffle +2 more
openaire +2 more sources
Insulin-Like Growth Factors and Aging
Endocrinology and Metabolism Clinics of North America, 1987Since its proposal three decades ago, the evidence in favor of the somatomedin hypothesis has been compelling. It is clear that somatotrophic actions of growth hormone are mediated through generation of insulin-like peptides and interaction of these peptides with plasma membrane receptors on sensitive cells. It is possible that such actions result from
openaire +2 more sources
2002
The insulin-like growth factor (IGF) system includes two peptide ligands, IGF-I and IGF-II; their receptors, the IGF-I receptor and the mannose-6-phosphate receptor, and six IGF-binding proteins. This family of growth factors plays fundamental roles in normal physiology and in neoplastic and metabolic disease states.
Derek Le Roith, Haim Werner
openaire +1 more source
The insulin-like growth factor (IGF) system includes two peptide ligands, IGF-I and IGF-II; their receptors, the IGF-I receptor and the mannose-6-phosphate receptor, and six IGF-binding proteins. This family of growth factors plays fundamental roles in normal physiology and in neoplastic and metabolic disease states.
Derek Le Roith, Haim Werner
openaire +1 more source
Receptors for insulin‐like growth factors
Journal of Internal Medicine, 1989U, Smith, J, Eriksson, P, Lönnroth
openaire +2 more sources
The somatomedin‐insulin‐like growth factors
Journal of Internal Medicine, 1989K, Hall, M, Tally
openaire +2 more sources