Results 261 to 270 of about 428,788 (310)

The Insulin-like Growth Factors and the Lung

American Journal of Respiratory Cell and Molecular Biology, 1990
Abstract The insulin-like growth factors (IGF-I and IGF-II) are peptides of about 7,500 D with structural homology to proinsulin that are capable of stimulating cellular proliferation and inducing differentiation. They are each encoded by single, large, complex genes that direct the transcription of multiple mRNAs.
A D, Stiles, A J, D'Ercole
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Insulin-like growth factor receptors

Journal of Cell Science, 1985
ABSTRACT There are two types of insulin-like growth factor (IGF) receptors. The type I receptor generally binds IGF-I more tightly than IGF-II and also interacts weakly with insulin. The type II receptor prefers IGF-II over IGF-I and does not recognize insulin.
S P, Nissley, J F, Haskell, N, Sasaki, M A, De Vroede, M M, Rechler   +4 more
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Insulin-like Growth Factors and the Basis of Growth

New England Journal of Medicine, 2003
Growth in any species is an extraordinarily complex process, but growth in humans is characterized by a number of unique features.
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH

Endocrinology and Metabolism Clinics of North America, 1996
The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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Insulin-Like Growth Factors and Aging

Endocrinology and Metabolism Clinics of North America, 1987
Since its proposal three decades ago, the evidence in favor of the somatomedin hypothesis has been compelling. It is clear that somatotrophic actions of growth hormone are mediated through generation of insulin-like peptides and interaction of these peptides with plasma membrane receptors on sensitive cells. It is possible that such actions result from
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Insulin-like growth factors and cancer

The Lancet Oncology, 2002
Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased recently because high serum concentrations of IGF1 are associated with an increased risk of breast, prostate, colorectal, and lung cancers. Physiologically, IGF1 is the major mediator of the effects of the growth hormone; it thus has a strong influence on ...
Gregor, Fürstenberger, Hans-Jörg, Senn
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Insulin-like growth factors in obstetrics

Current Opinion in Obstetrics and Gynecology, 2000
Data from a number of studies reported during the past two decades indicate that the insulin-like growth factor (IGF) system, including IGF-I and IGF-II, their receptors and six high-affinity binding proteins, is involved in the control of foetal and placental growth and development. Recent studies that addressed the role of the IGF system in pregnancy
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Downstream Insulin-Like Growth Factor

2012
Until 10 years ago genetic defects that cause a child to be born small for gestational age (SGA) were poorly defined. With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a ...
Roland, Pfäffle, Wieland, Kiess, Jürgen, Klammt   +2 more
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Actions of Insulin-Like Growth Factors

Annual Review of Physiology, 1985
Three different lines of research and three entirely different observations have led to the discovery of the insulin-like growth factors (IGFs). In 1957, Salmon & Daughaday carried out an important experiment (44). They observed that serum stimulated the incorporation of 35S into incubated cartilage.
E R, Froesch, C, Schmid, J, Schwander, J, Zapf   +3 more
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Insulin-like Growth Factors and Cancer

Annals of Internal Medicine, 1995
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these ...
D, LeRoith, R, Baserga, L, Helman, C T, Roberts   +3 more
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