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Actions of Insulin-Like Growth Factors
Annual Review of Physiology, 1985Three different lines of research and three entirely different observations have led to the discovery of the insulin-like growth factors (IGFs). In 1957, Salmon & Daughaday carried out an important experiment (44). They observed that serum stimulated the incorporation of 35S into incubated cartilage.
E R, Froesch +3 more
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Insulin-like Growth Factors and the Basis of Growth
New England Journal of Medicine, 2003Growth in any species is an extraordinarily complex process, but growth in humans is characterized by a number of unique features.
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INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH
Endocrinology and Metabolism Clinics of North America, 1996The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as ...
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The Insulin-like Growth Factors and the Lung
American Journal of Respiratory Cell and Molecular Biology, 1990Abstract The insulin-like growth factors (IGF-I and IGF-II) are peptides of about 7,500 D with structural homology to proinsulin that are capable of stimulating cellular proliferation and inducing differentiation. They are each encoded by single, large, complex genes that direct the transcription of multiple mRNAs.
A D, Stiles, A J, D'Ercole
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Insulin-like growth factors and cancer
The Lancet Oncology, 2002Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased recently because high serum concentrations of IGF1 are associated with an increased risk of breast, prostate, colorectal, and lung cancers. Physiologically, IGF1 is the major mediator of the effects of the growth hormone; it thus has a strong influence on ...
Gregor, Fürstenberger, Hans-Jörg, Senn
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Insulin-like growth factors in obstetrics
Current Opinion in Obstetrics and Gynecology, 2000Data from a number of studies reported during the past two decades indicate that the insulin-like growth factor (IGF) system, including IGF-I and IGF-II, their receptors and six high-affinity binding proteins, is involved in the control of foetal and placental growth and development. Recent studies that addressed the role of the IGF system in pregnancy
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Insulin-like Growth Factors and Cancer
Annals of Internal Medicine, 1995The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these ...
D, LeRoith +3 more
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Insulin-Like Growth Factors, Nutrition and Growth
2013Nutritional status is a key factor in the regulation of human linear growth. The growth hormone (GH)-IGF axis consists of a cascade of finely tuned molecular mechanisms which are vulnerable to protein-calorie deficiency. The most notable evidence for this is the presence of IGF-1 deficiency, that can be caused by failure of a number of processes ...
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Insulin-like growth factors and neoplasia
Nature Reviews Cancer, 2004The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating cellular proliferation and apoptosis. Converging results from epidemiological research and in vivo carcinogenesis models indicate that high levels of circulating IGF1 are associated with increased risk of several common cancers.
Michael N, Pollak +2 more
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The Phylogeny of the Insulin-like Growth Factors
1998The insulin-like growth factors are major regulators of growth and development in mammals and their presence in lower vertebrates suggests that they played a similarly fundamental role throughout vertebrate evolution. While originally perceived simply as mediators of growth hormone, on-going research in mammals has revealed several hierarchical layers ...
Reinecke M, Collet C
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