Results 211 to 220 of about 635,173 (353)
Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential. [PDF]
Curr Issues Mol BiolHsieh WJ, Qiu WY, Percec I, Chang TM.
europepmc +1 more source
Insulin‐like growth factor‐1 promotes the testicular sperm production by improving germ cell survival and proliferation in high‐fat diet‐treated male mice [PDF]
Guoqiang Liu +6 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source
A cross-sectional study of urinary sodium, cardiac remodeling, and the mediating role of insulin-like growth factor-1: Insights from the UK Biobank. [PDF]
Medicine (Baltimore)Yan D, Gao D, Yuan M.
europepmc +1 more source
Variant in the 5′ Untranslated Region of Insulin-Like Growth Factor 1 Receptor Is Associated With Susceptibility to Mastitis in Cattle [PDF]
, 2012 Mayumi Sugimoto, Yoshikazu Sugimoto
openalex +1 more source
Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source