Results 281 to 290 of about 714,864 (392)

Targeting the insulin-like growth factor-1 receptor to overcome imatinib resistance in chronic myeloid leukemia. [PDF]

Discov Oncol
Okabe S, Arai Y, Gotoh A.
europepmc   +1 more source

Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions

Circulation, 2009
L. Elia, R. Contu, M. Quintavalle, Francesca Varrone, C. Chimenti, M. Russo, Vincenzo Cimino, L. De Marinis, A. Frustaci, D. Catalucci, G. Condorelli   +10 more
semanticscholar   +1 more source

MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang, Min‐Ying Huang, Shao‐Ying Yang, Jia‐Yang Cai, Qian Zhao, Fang‐Lin Zhang, Xin Hu, Zhi‐Min Shao, Li Liao, A‐Yong Cao, Da‐Qiang Li   +10 more
wiley   +1 more source

Response to Commentary on 'Diminished levels of insulin-like growth factor-1 may be a risk factor for peripheral neuropathy in type 2 diabetes patients'. [PDF]

J Diabetes Investig
Zhong J, Lin X, Zheng X, Zhou Y, Huang H, Xu L.   +5 more
europepmc   +1 more source

Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

Circulation Research, 2004
D. Torella, M. Rota, D. Nurzynska, E. Musso, Alyssa Monsen, I. Shiraishi, E. Zias, K. Walsh, A. Rosenzweig, Mark A Sussman, K. Urbanek, B. Nadal-Ginard, J. Kajstura, P. Anversa, A. Leri   +14 more
semanticscholar   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

CircRNA-NOLC1 mediates Insulin-like growth factor 1 receptor via performing as a ceRNA of miRNA-140-5p to facilitate testicular germ cell tumor advancement. [PDF]

Clinics (Sao Paulo)
Lin F, Yao X, Zhang S, Yang H.
europepmc   +1 more source

Glutamate concentration in plasma, erythrocyte and muscle in relation to plasma levels of insulin-like growth factor (IGF)-I, IGF binding protein-1 and insulin in patients on haemodialysis

, 1998
JC Divino Filho, Susan Hazel, Peter Fürst, Jonas Bergström, Kerstin Hall   +4 more
openalex   +1 more source

Growth hormone, insulin-like growth factor-1 and the aging brain

Experimental Gerontology, 2015
N. Ashpole, Jessica E. Sanders, Erik L. Hodges, Han Yan, W. Sonntag   +4 more
semanticscholar   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source