Results 151 to 160 of about 31,695,425 (269)

LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway [PDF]

, 2023
Peng Xu, Daxiong Feng, Jun Wang, Yaodong Wang, Gang Xie, Bin Zhang, Xiaohan Li, Jiawei Zeng, Jiafu Feng   +8 more
openalex   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Study of Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Congenital Heart Disease [PDF]

Hajer Ali Al Mesmari, Tarek Mustafa El Walili, Akram Abdel Moneim Deghady, Rania Mohamed Abdelsadek Elhaddad   +3 more
openalex   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Role of Insulin-Like Growth Factor Binding Protein-3 in the Pathogenesis of Herpes Stromal Keratitis. [PDF]

Invest Ophthalmol Vis Sci, 2020
Rao P, Suvas PK, Jerome AD, Steinle JJ, Suvas S.   +4 more
europepmc   +1 more source

Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-κB/IL-6/ROS signaling. [PDF]

J Exp Clin Cancer Res, 2021
Wang SH, Chen YL, Hsiao JR, Tsai FY, Jiang SS, Lee AY, Tsai HJ, Chen YW.   +7 more
europepmc   +1 more source

Correction: Aggravation of post-ischemic liver injury by overexpression of insulin-like growth factor binding protein 3

Lu Zhou, Hyoung-Won Koh, Ui-Jin Bae, Byung‐Hyun Park   +3 more
openalex   +1 more source

Expression of Insulin-like growth factor 2 mRNA-binding protein 3 and its diagnostic value in breast cancer [PDF]

Chaoqun Wang, Jun-Kang Shao, Yan Wang, Shi-Ping Lu, Lijing Jiang, Zhi-Qun Du, Bifei Huang   +6 more
openalex   +1 more source