Results 171 to 180 of about 31,695,425 (269)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. [PDF]

Aging (Albany NY), 2020
Vassilieva I, Kosheverova V, Vitte M, Kamentseva R, Shatrova A, Tsupkina N, Skvortsova E, Borodkina A, Tolkunova E, Nikolsky N, Burova E.   +10 more
europepmc   +1 more source

Additional file 1 of Associations of insulin-like growth factor 1 and IGF binding proteins 2 and 3 with lipids in toddlers

Johanna Neiß, Hans Demmelmair, Fabian Geyer, Alexander Triebswetter, Dudung Angkasa, Joaquín Escribano, Natalia Ferré, Mariona Gispert‐Llauradó, B. Koletzko, Susanne Bechtold-Dalla Pozza, Veit Grote   +10 more
openalex   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Insulin-like Growth Factor 1, but Not Insulin-Like Growth Factor-Binding Protein 3, Predicts Central Precocious Puberty in Girls 6-8 Years Old: A Retrospective Study.

Horm Res Paediatr, 2021
Escagedo PD, Deal CL, Dwyer AA, Hauschild M.   +3 more
europepmc   +1 more source

Individuazione e studio del comportamento del sistema “Insulin Like Growth Factor-1 – Insulin Like Growth Factor Binding Proteins” nel liquido sulculare durante il movimento dentale

, 2004
.IGF-1 (Insulin-like growth factor-1) is a growth factor whose biological activity at cellular level is regulated by 6 binding proteins (IGFBs); one of them, IGFBP-3, is the most abundant in blood.
GANDINI, PAOLA, Federico Giovanni, Saggese Rinaldina   +2 more
core  

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Insulin-like growth factor 2 mRNA-binding protein 3 （IMP3） expression in colorectal cancer with liver metastasis

Marin Hojo, Eisuke Shiozawa, Hiromi Ikeda, Yumika Takano, Seiya Chiba, Takuya Terunuma, Yuichiro Mochizuki, Yo Sasaki, Takahiro Hobo, Tadanori Yamochi, Miki Kushima, Noboru Yokoyama, Toshiko Yamochi   +12 more
openalex   +2 more sources

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Insulin-like growth factor-binding protein 3 regulates collagen production via TGF-β-Smad2/3 pathway and osteogenic differentiation related with phosphorylation of Akt in human periodontal ligament-derived cell line

Shuxin Wang, Hiromi Mitarai, Hiroko Wada, Ziqing Ran, Asuka Yuda, Akira Haraguchi, Weihao Sun, Jiawen Lin, Hidefumi Maeda, Naohisa Wada   +9 more
openalex   +1 more source