Results 31 to 40 of about 242,633 (111)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

BMC Endocrine Disorders, 2018
Background Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP).
Hua-Pin Chang, Shun-Fa Yang, Shu-Li Wang, Pen-Hua Su   +3 more
doaj   +1 more source

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases

Molecular Medicine
The oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors.
Shuangping Ma, Yiran Qin, Wenjie Ren
doaj   +1 more source

Polyploid Adipose Stem Cells Shift the Balance of IGF1/IGFBP2 to Promote the Growth of Breast Cancer

Frontiers in Oncology, 2020
Background: The close proximity of adipose tissue and mammary epithelium predispose involvement of adipose cells in breast cancer development. Adipose-tissue stem cells (ASCs) contribute to tumor stroma and promote growth of cancer cells. In our previous
Roberta Fajka-Boja, Gábor J. Szebeni, Gábor J. Szebeni, Éva Hunyadi-Gulyás, László G. Puskás, László G. Puskás, Róbert L. Katona   +6 more
doaj   +1 more source

Prognostic value of IGFBP2 in various cancers: a systematic review and meta‐analysis

Cancer Medicine, 2022
Background The prognostic significance of insulin‐like growth factor binding protein 2 (IGFBP2) expression has been explored in plenty of studies in human cancers.
Biao Zhang, Chao‐Qun Hong, Yu‐Hao Luo, Lai‐Feng Wei, Yun Luo, Yu‐Hui Peng, Yi‐Wei Xu   +6 more
doaj   +1 more source

Research progress of IGF-1 and IGFBP-3 in type 2 diabetes and its microvascular complications

生物医学转化
The prevalence of type 2 diabetes mellitus (T2DM) and its microvascular complications is increasing year by year, posing a serious threat to human health and greatly increasing the socioeconomic burden.
Huang Shuting, Yang Yang
doaj   +1 more source

A tissue-engineered human psoriatic skin model: targeting inflammation and glucose metabolism dysregulation in psoriasis using microneedle patches

Frontiers in Molecular Biosciences
Psoriasis, an inflammatory skin disease, affects nearly 43 million individuals globally, and patients are 59% more likely to have type 2 diabetes. In this study, tissue-engineered psoriatic human skin substitutes were produced using keratinocytes and ...
Yasmine Ruel, Yasmine Ruel, Fatma Moawad, Sergio Cortez Ghio, Davide Brambilla, Davide Brambilla, Roxane Pouliot, Roxane Pouliot   +7 more
doaj   +1 more source

Protein Biomarkers of Cardiovascular Disease and Mortality in the Community

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk‐stratification methods and may be informative regarding biological pathways contributing to disease.
Jennifer E. Ho, Asya Lyass, Paul Courchesne, George Chen, Chunyu Liu, Xiaoyan Yin, Shih‐Jen Hwang, Joseph M. Massaro, Martin G. Larson, Daniel Levy   +9 more
doaj   +1 more source

Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling

JCI Insight, 2023
Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the posttranslational protein modification.
Dongyan Song, Jingyue Shang, Yinyi Long, Menghua Zhong, Li Li, Jiongcheng Chen, Yadie Xiang, Huishi Tan, Haili Zhu, Xue Hong, Fan Fan Hou, Haiyan Fu, Youhua Liu   +12 more
doaj   +1 more source

IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions

Frontiers in Endocrinology, 2019
Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the IGFBPs in the cerebrospinal fluid (CSF), and developing brain showed the ...
Shumsuzzaman Khan
doaj   +1 more source

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Stem Cells International, 2018
RNA-binding proteins (RBPs) mediate the localization, stability, and translation of the target transcripts and fine-tune the physiological functions of the proteins encoded. The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family
Junguo Cao, Qingchun Mu, Haiyan Huang
doaj   +1 more source