Results 71 to 80 of about 206,404 (257)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Prognostic impact of insulin‐like growth factor‐I and its binding proteins, insulin‐like growth factor‐I binding protein‐2 and ‐3, on adverse histopathological features and survival outcomes after radical cystectomy

, 2022
OBJECTIVES: Insulin‐like growth factor‐I and its binding proteins are involved in cancer development, progression, and metastasis. In urothelial carcinoma, the impact of this pathway is still poorly investigated.
Satoshi Katayama, Grossmann, Nico C., Katayama, Satoshi, Mori, Keiichiro, Mostafai, Hadi, Richard Lee, Sari Motlagh, Reza, Comprate, Eva, Victor M Schuettfort, Pierre I Karakiewicz, Pawel Rajwa, Fahad Quhal, Keiichiro Mori, Rajwa, Pawel, Abdulmajeed Aydh, Laukhtina, Ekaterina, Shahrokh F Shariat, Benjamin Pradere, Schuettfort, Victor M, Abufaraj, Mohammad, Gontero, Paolo, Nico C Grossmann, Mohammad Abufaraj, Yair Lotan, Shariat, Shahrokh F., Quhal, Fahad, Lee, Richard, Shariat, Shahrokh F, Ekaterina Laukhtina, Karakiewicz, Pierre I., Aydh, Abdulmajeed, Karakiewicz, Pierre I, Lotan, Yair, Grossmann, Nico C, Reza Sari Motlagh, Eva Comprate, Moschini, Marco, Paolo Gontero, Pradere, Benjamin, Marco Moschini, Hadi Mostafai, Schuettfort, Victor M.   +41 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Individuazione e studio del comportamento del sistema “Insulin Like Growth Factor-1 – Insulin Like Growth Factor Binding Proteins” nel liquido sulculare durante il movimento dentale

, 2004
.IGF-1 (Insulin-like growth factor-1) is a growth factor whose biological activity at cellular level is regulated by 6 binding proteins (IGFBs); one of them, IGFBP-3, is the most abundant in blood.
GANDINI, PAOLA, Federico Giovanni, Saggese Rinaldina   +2 more
core  

Insulin-like growth factor binding proteins (IGFBPs) in camels : revelation by western ligand blotting and partial purification of insulin-like growth factor binding protein-3 (IGFBP3) [PDF]

, 2004
It's well known that Insulin-like growth factor binding proteins (IGFBPs) are important in somatotrope axis in mammals. They modulate bioactivity of Insulin-like growth factor-I/II.
Hammadi, Mohamed, Renaville, Robert, Khorchani, Touhami, Moshlah, Mekki, Portetelle, Daniel, Colinet, Frédéric   +5 more
core  

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin' [PDF]

, 2005
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin.
Guild, Simon, Lissa R. Herron, Brophy, Peter J, Prystowsky, Michael B., Margaret Brandwein-Gensler, Michael B. Prystowsky, Gavin I. Welsh, Gunn-Moore, Frank J., Venkateswarlu, Kanamarlapudi, Tavaré, Jeremy M, Tavaré, Jeremy M., Gunn-Moore, Francis James, Frank J. Gunn-Moore, Tavaré, JM, Herron, Lissa R, Herron, Lissa R., Gillespie, Stewart, Brannigan, Frances, Prystowsky, M, Stewart Gillespie, Prystowsky, Michael B, Welsh, Gavin I., Frances Brannigan, Tavare, J, Welsh, Gavin I, Welsh, GI, Prystowsky, MB, Kanamarlapudi Venkateswarlu, Brophy, P, Herron, LR, Simon Guild, Brandwein-Gensler, M, Madan, R, Peter J. Brophy, Gunn-Moore, FJ, Gillespie, S, Brophy, Peter J., Rashna Madan, Brannigan, F, Welsh, G, Gunn-Moore, Frank J, Brandwein-Gensler, Margaret, Venkateswarlu, K, Guild, S, Madan, Rashna, Jeremy M. Tavaré, Brophy, PJ, Herron, L, Venkat Kanamarlapudi   +48 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source