Insulin-Like Growth Factor-I Resistance* [PDF]
Endocrine Reviews, 1998 I. Introduction II. The IGFs and Their Receptors III. Genetically Engineered Mouse Models IV. Malnutrition V. Conditions Associated with Genetic IGF-I Resistance in Humans A. African Efe Pygmies B. Leprechaunism and other genetic disorders associated with severe insulin resistance C. Deletions of the distal arm of chromosome 15 D.
Suparna Jain +3 more
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Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2012 Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition.The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD).In this multicentric cross-sectional study, 694 elderly subjects (
Joël Coste +13 more
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Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Human Keratinocyte Cell Line HaCaT [PDF]
, 1995 The human keratinocyte cell line HaCaT has a basal phenotype and secretes an insulin-like growth factor (IGF) binding protein, IGFBP-3, which modulates its IGF-I response.
Werther, George A. +1 more
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The visceral adiposity index is associated with insulin sensitivity and IGF-I levels in adults with growth hormone deficiency [PDF]
, 2016 The visceral adiposity index, based on anthropometric and metabolic parameters, has been shown to be related to adipose tissue function and insulin sensitivity.
Ciresi, A. +3 more
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How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. [PDF]
, 2020 Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of
Croll, Tristan I +9 more
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Growth Regulation by Insulin-like Growth Factor-I in Fish [PDF]
Bioscience, Biotechnology, and Biochemistry, 2000 Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that plays an essential role in the regulation of development and somatic growth of vertebrates, mainly by mediating growth hormone actions. It has clearly been established that the structure of IGF-I and its biological function has been highly conserved among vertebrates.
Moriyama, Shunsuke +2 more
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Insulin-like growth factor -I deficiency, insulin sensitivity, and glucose metabolism [PDF]
, 2013 In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin resistance by lipolysis. In contrast,
Ekström, Klas
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Insulin-like growth factor I during growth in bulls [PDF]
Reproduction Nutrition Développement, 1989 In 10 bulls, changes in blood plasma concentrations of insulin-like growth factor I (IGF1) were studied during rearing and during the ensuing growth period. IGF1 continuously increased from 32 micrograms/l at the age of 15 d to 194 micrograms/l at the age of 307 d together with body weight.
J. Blum, H. Ronge
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Measurement of Salivary Insulin-Like Growth Factor-I in Acromegaly: Comparison with Serum Insulin-Like Growth Factor-I and Growth Hormone Concentrations [PDF]
cclm, 1994 The aim of this study was to establish the concentration of insulin-like growth factor-I (IGF-I) in saliva of acromegalic patients, and to compare it with the basal levels of serum IGF-I and growth hormone. IGF-I was determined in extracted serum or neat saliva by a disequilibrium RIA using antibodies and iodinated ligand from Amersham and WHO 87/518 ...
Halimi, S. +5 more
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IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]
, 2012 The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea +3 more
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