Results 191 to 200 of about 356,438 (307)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. [PDF]

Front Endocrinol (Lausanne)
Yuen KCJ, Hjortebjerg R, Ganeshalingam AA, Clemmons DR, Frystyk J.   +4 more
europepmc   +1 more source

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. [PDF]

Front Aging Neurosci, 2021
Zegarra-Valdivia JA, Chaves-Coira I, Fernandez de Sevilla ME, Martinez-Rachadell L, Esparza J, Torres-Aleman I, Nuñez A.   +6 more
europepmc   +1 more source

Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice

, 2011
Emily J. Mason, Jacquelyn A. Grell, Junxiang Wan, Pinchas Cohen, Cheryl A. Conover   +4 more
openalex   +2 more sources

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Associations between Bronchopulmonary Dysplasia, Insulin-like Growth Factor I and Nutrition. [PDF]

Nutrients
Yumani DFJ, Walschot FH, Lafeber HN, van Weissenbruch MM.   +3 more
europepmc   +1 more source

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Proceedings of the National Academy of Sciences of the United States of America, 2008
Y. Suh, G. Atzmon, Miook Cho, David Hwang, Bingrong Liu, D. Leahy, N. Barzilai, P. Cohen   +7 more
semanticscholar   +1 more source

Insulin-like Growth Factor I Reverses Experimental Diabetic Autonomic Neuropathy [PDF]

, 1999
Robert E. Schmidt, Denise Dorsey, Lucie N. Beaudet, Santiago B. Plurad, Curtis A. Parvin, Matthew S. Miller   +5 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

The Effects of Juglone on Cell Proliferation and Insulin-Like Growth Factor I Receptor/Phosphoinositide 3-Kinase/p85 (IGF-IR/PI3K/p85) Signaling Pathway in Pancreatic Cancer. [PDF]

J Clin Pract Res
Dursunoğlu D, Arikoğlu H, Kaya DE, Göktürk F.   +3 more
europepmc   +1 more source