Results 261 to 270 of about 536,129 (311)

Defining Insulin-Like Growth Factor-I Deficiency

Hormone Research, 2006
• The GH-IGF system should be viewed like other endocrine systems, with a central, trophic hormone (GH) and a peripherally active hormone (IGF-I). • A decrease in IGF-I production, without a concomitant impairment in GH secretion, should be termed 'Primary IGF deficiency'.
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Growth hormone, insulin‐like growth factor I, and motoneuron size

Journal of Neurobiology, 1997
In this study we asked whether growth hormone (GH) and one of its key mediators, insulin-like growth factor I (IGF-I), influence spinal motoneuron size in conjunction with whole body size. We present evidence that GH has such a role, possibly without the mediation of IGF-I.
L, Chen, P K, Lund, S B, Burgess, B E, Rudisch, D L, McIlwain   +4 more
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Insulin-like growth factor-I and cancer risk

Growth Hormone & IGF Research, 2004
Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on ...
Yasir H, Ibrahim, Douglas, Yee
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Insulin‐like growth factor I in growing thoroughbreds

Journal of Animal Physiology and Animal Nutrition, 2007
SummaryThe objective of this longitudinal study was to characterize growth and plasma insulin‐like growth factor I (IGF‐I) concentrations in pasture‐raised thoroughbreds fed two sources of dietary energy. Mares and foals were randomly assigned to either a sugar and starch (SS) or fat and fibre (FF)‐rich feed, and plasma IGF‐I and growth were measured ...
W B, Staniar, D S, Kronfeld, R M, Akers, P A, Harris   +3 more
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Insulin-Like Growth Factor-I in Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition, 1994
To contribute to the description of the physiopathological mechanisms of celiac disease, changes in insulin-like growth factor I (IGF-I) were followed-up in 21 children suspected of suffering from celiac disease. Thirteen children were suffering from celiac disease according to the original criteria of the European Society of Paediatric ...
B, Weile, P A, Krasilnikoff, A, Giwercman, N E, Skakkebaek   +3 more
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Exercise and Circulating Insulin-Like Growth Factor I

Hormone Research in Paediatrics, 2004
Determinations of serum concentrations of total insulin-like growth factor I (tIGF-I) are important in the diagnosis, monitoring of treatment and safety evaluation of patients with growth disorders and/or metabolic disease. It is well established that tIGF-I status varies over time.
Ulrika, Berg, Peter, Bang
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Drug delivery of Insulin-like growth factor I

European Journal of Pharmaceutics and Biopharmaceutics, 2015
This review starts off outlining the control of Insulin-like growth factor I (IGF-I) kinetics in Nature and by virtue of a complex system of 6 binding proteins controlling half-life and tissue distribution of this strong anabolic peptide. In addition, alternative splicing is known to result in IGF-I variants with modulated properties in vivo and this ...
Isabel Schultz, Joel Wurzel, Lorenz Meinel   +2 more
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Clinical Uses of Insulin-like Growth Factor I

Annals of Internal Medicine, 1994
Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions. The therapeutic potential of recombinant human IGF-I treatment is being investigated in various growth hormone-resistant and insulin-resistant disorders. Recent studies have shown that IGF-I may substitute for growth hormone in promoting linear
C A, Bondy, L E, Underwood, D R, Clemmons, H P, Guler, M A, Bach, M, Skarulis   +5 more
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Nutritional regulation of insulin-like growth factor-I

Metabolism, 1995
Several lines of evidence indicate that in the human, insulin-like growth factor-I (IGF-I) is nutritionally regulated. Both energy and protein availability are required for maintenance of IGF-I. Measurements of serum IGF-I constitute a sensitive means for monitoring the response of acutely ill patients to nutritional intervention.
J M, Ketelslegers, D, Maiter, M, Maes, L E, Underwood, J P, Thissen   +4 more
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Mecasermin (recombinant human insulin-like growth factor I)

Advances in Therapy, 2009
Growth hormone (GH) exercises its growth effects by stimulating insulin-like growth factor I (IGF-I) synthesis in the liver (endocrine IGF-I) and by inducing chondrocyte differentiation/replication and local production of IGF-I (paracrine/autocrine IGF-I).
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