Results 31 to 40 of about 513,537 (263)
Human conditions of insulin-like growth factor-I (IGF-I) deficiency
Journal of Translational Medicine, 2012 Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
Puche Juan E, Castilla-Cortázar Inma
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Frontiers in Pediatrics, 2018 Background: We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD).Methods: We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-
Sara Pagani +7 more
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Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain [PDF]
, 2016 Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Collinsová, Michaela +13 more
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Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]
, 2017 Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F +6 more
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Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2009 Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model of IGF-IR overexpression in the lung has not been created.
Nicolle M. Linnerth +6 more
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Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]
, 1994 Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
Blum, Werner F. +4 more
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Ovarian Insulin-Like Growth Factor-I
Agricultural Science Digest - A Research Journal, 2020 The insulin-like growth factor-I is a pleotropic growth factor that modulates cell replication. Insulin-like growth factor-I is produced by granulosa, theca and luteal cells and have autocrine and paracrine actions. It plays a crucial role in animal fertility acting as a monitoring signal.
M. Bijna, K. Karthiayini
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Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies
Neurobiology of Disease, 2001 The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes.
J.Robinson Singleton, Eva L. Feldman
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Endocrine Regulations, 2022 Objective. Micromegaly describes a subgroup of patients with clinically evident acromegaly and elevated insulin-like growth factor I (IGF-I) with apparently normal basal growth hormone (bGH) and often a glucose-suppressed growth hormone (GH) of
Inacio Isabel +7 more
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Frontiers in Endocrinology, 2023 IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation.
Stefania Stella +13 more
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