Results 81 to 90 of about 394,398 (350)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro.
E M, Zimmermann, L, Li, Y T, Hou, N K, Mohapatra, J B, Pucilowska   +4 more
openaire   +2 more sources

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Kelly, S.M., Tonner, Elizabeth, Gow, I.F., Gow, Iain F, Clegg, Roger A, Allan, Gordon J., Clegg, Roger A., Beattie, J., Beattie, James, Flint, David J., Allan, G.J., Flint, D.J., Gow, Iain F., Shand, J., Tonner, E., Szymanowska, M., Phillips, K., Shand, John H, Allan, Gordon J, Phillips, Kirsten, Kelly, Sharon M, Clegg, R.A., Shand, John H., Flint, David J, Szymanowska, Malgorzata, Kelly, Sharon M.   +25 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2012
Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition.The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD).In this multicentric cross-sectional study, 694 elderly subjects (
Duron, Emmanuelle, Funalot, Benoît, Brunel, Nadège, Coste, Joël, Quinquis, Laurent, Viollet, Cécile, Belmin, Joël, Jouanny, Pierre, Pasquier, Florence, Tréluyer, Jean-Marc, Epelbaum, Jacques, Le Bouc, Yves, Hanon, Olivier   +12 more
openaire   +3 more sources

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved*

Journal of Biological Chemistry, 2002
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) have a highly homologous structure, but different biological effects. Insulin and IGF-I half-receptors can heterodimerize, leading to the formation of insulin/IGF-I hybrid ...
G. Pandini, F. Frasca, R. Mineo, L. Sciacca, R. Vigneri, A. Belfiore   +5 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Regulation of insulin and insulin-like activity in malnourished patients with carcinoma ventriculi subjected to total gastrectomy and personalized nutritional support [PDF]

Journal of Medical Biochemistry, 2016
Background: Insulin and insulin-like growth factor (IGF) activities are disturbed during critical illness. Time-course changes in the concentrations of insulin, IGF-I and IGFbinding proteins (IGFBPs) were monitored in this study and their correlation ...
Nedić Olgica N., Miljuš Goran, Malenković Vesna   +2 more
doaj  

How ligand binds to the type 1 insulin-like growth factor receptor

Nature Communications, 2018
The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like
Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence   +9 more
doaj   +1 more source