Results 1 to 10 of about 418,496 (299)

Insulin-like growth factor-II: new roles for an old actor [PDF]

Frontiers in Endocrinology, 2012
IGF-II, traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator.
Stefano eCianfarani
doaj   +4 more sources

Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report [PDF]

Surgical Case Reports, 2023
Background Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that
Noriyuki Nishiwaki, Yoshihiro Mikuriya, Fumiaki Takatsu, Ryoji Ochiai, Tomokazu Kakishita, Naruyuki Kobayashi, Takaya Kobatake, Shinji Hato, Norihiro Teramoto, Mototsugu Nagao, Izumi Fukuda, Koji Ohta   +11 more
doaj   +2 more sources

Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study [PDF]

Life, 2021
Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome ...
Daniel Åberg, N. David Åberg, Katarina Jood, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern, Johan Svensson   +7 more
doaj   +2 more sources

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease [PDF]

Redox Biology, 2021
Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez, Nadia Valverde, David Ladrón de Guevara-Miranda, Estrella Lara, Yanina S. Romero-Zerbo, Carmelo Millon, Federica Boraldi, Fabiola Ávila-Gámiz, Ana M. Pérez-Cano, Pablo Garrido-Gil, Jose Luis Labandeira-Garcia, Luis J. Santin, Jose Pavia, Maria Garcia-Fernandez   +13 more
doaj   +2 more sources

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. [PDF]

J Biol Chem, 2016
Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Hexnerová R, Křížková K, Fábry M, Sieglová I, Kedrová K, Collinsová M, Ullrichová P, Srb P, Williams C, Crump MP, Tošner Z, Jiráček J, Veverka V, Žáková L.   +13 more
europepmc   +4 more sources

Temporal expression pattern of the insulin-like growth factor II and fibroblast growth factor transcripts in avian embryogenesis [PDF]

Brazilian Archives of Biology and Technology, 2008
In this study, the abundance of IGF-II and bFGF transcripts was estimated in the chicken embryos using the competitive RT-PCR analysis. Significant enhancements in the abundance of IGF-II mRNA were observed at stages HH1 and 5, and a new accumulation in ...
Jane Eyre Gabriel, Lúcia Elvira Alvares, Luiz Lehmann Coutinho   +2 more
doaj   +4 more sources

Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis.
Silas Otero Reis Salum, Eduardo Batista Candido, Maria Aparecida Custódio Domingues, Elida Paula Benquique Ojopi, Ângela Favorito Santarem Tonon, Agnaldo Lopes da Silva-Filho   +5 more
doaj   +2 more sources

Relationship between Metal Pollution and Gene Expression of Insulin-like Growth Factor II [PDF]

Journal of Health and Pollution, 2018
Background. Metals pollution plays an important role in the regulation of gene expression through interference with signal transduction pathways which are important for cell bioactivity. Objectives.
Aziza A. Saad, Amany El-Sikaily, Maher A. Kamel, Hany Kassem, Mohamed S. Abdel-Latif   +4 more
doaj   +2 more sources

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine [PDF]

Stem Cell Reports, 2019
Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches.
Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison   +12 more
doaj   +2 more sources

A novel tumour enhancer function of Insulin-like growth factor II mRNA-binding protein 3 in colorectal cancer. [PDF]

Cell Death Dis, 2023
Di Fusco D, Di Grazia A, Di Maggio G, Segreto MT, Iannucci A, Maresca C, De Stefano A, Sica G, Stolfi C, Monteleone G, Monteleone I.   +10 more
europepmc   +3 more sources