Results 91 to 100 of about 463,657 (378)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes [PDF]

, 2002
Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes.BackgroundIn children with chronic renal failure (CRF), impairment of longitudinal growth is in part due to excess amounts of ...
Durham, Susan K., Kiepe, Daniela, Mehls, Otto, Powell, David R., Tönshoff, Burkhard, Ulinski, Tim   +5 more
core   +1 more source

Doege–Potter syndrome due to endothoracic solitary hypoglycemic fibrous tumor

Clinical Case Reports, 2022
Doege–Potter syndrome leads to severe and sustained symptomatic hypoglycemia and is associated with the solitary fibrous tumor. It is a rare cause, and its diagnosis requires a clinical suspicion and other markers such as insulin‐like growth factor II ...
Madaleine Lopez‐Hinostroza, Jeel Moya‐Salazar, Juan Dávila, Angélica Y. Absencio, Hans Contreras‐Pulache   +4 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The Role of the Insulin-Like Growth Factors and Their Binding Proteins in Glucose Homeostasis [PDF]

, 2003
The insulin like growth factors (IGF-I and -II) are structurally and functionally related to insulin. While insulin is a key regulator of glucose homeostasis over the short term, emerging evidence suggests that the IGFs are involved in the longer term ...
Murphy, Liam J.
core   +2 more sources

Identification and characterization of single nucleotide polymorphisms in 12 chicken growth-correlated genes by denaturing high performance liquid chromatography

Genetics Selection Evolution, 2005
The genes that are part of the somatotropic axis play a crucial role in the regulation of growth and development of chickens. The identification of genetic polymorphisms in these genes will enable the scientist to evaluate the biological relevance of ...
Yang Guanfu, Zeng Hua, Ouyang Jianhua, Lei Mingming, Nie Qinghua, Zhang Xiquan   +5 more
doaj   +1 more source

Organization of the human genes for insulin‐like growth factors I and II [PDF]

FEBS Letters, 1986
Recently, we have reported the isolation of cDNAs encoding the precursors of insulin‐like growth factors I and II (IGF‐I and II) [(1983) Nature 306, 609‐611; (1985) FEBS Lett. 179, 243‐246. These cDNAs were employed as specific probes to detect and isolate the corresponding genes from human cosmid DNA libraries.
G.M. Verduijn, Marnix Jansen, F.M.A. van Schaik, Bonno N. Bouma, P. de Pagter-Holthuizen, G.J.B. van Ommen, John S. Sussenbach   +6 more
openaire   +3 more sources

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

Journal of Clinical Investigation, 1989
Insulin-like growth factor II (IGF-II) mRNA was increased in two of eight neuroblastomas and in eight of eight pheochromocytomas, tumors of the adrenal medulla that occur in childhood and adulthood, respectively. RNA encoding the type I IGF receptor, the
O. El-Badry, J. A. Romanus, L J Helman, M. J. Cooper, M. Rechler, M A Israel   +5 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R [PDF]

, 2016
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II ...
Abell, Andrew D, Brimble, Margaret Anne, Cottam Jones, Jade M, Forbes, Briony E, Harris, Paul William Richard, Scanlon, Denis B   +5 more
core   +1 more source