Results 91 to 100 of about 470,139 (379)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin.
Anastasios Papaioannou, Serdar Kuyucak, Zdenka Kuncic   +2 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. II. Body Composition [PDF]

, 2007
The current study is a comprehensive genome analysis to detect QTL affecting metabolic traits in chickens. Two unique F2 crosses generated from a commercial broiler male line and 2 genetically distinct inbred lines (Leghorn and Fayoumi) were used in the ...
Ashwell, C. M., Evock-Clover, C. M., Lamont, Susan, Lamont, Susan, McMurtry, J. P., Zhou, H.   +5 more
core   +5 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

SHIP2: A ‘‘NEW’’ Insulin Pathway Target for Aging Research [PDF]

, 2014
Strong evidence suggests that systemic inflammation and central adiposity contribute to and perpetuate metabolic syndrome. All of these alterations predispose individuals to type 2 diabetes mellitus (T2DM), cardiovascular disease, as well as Alzheimer ...
ACCARDI, Giulia, BALISTRERI, Carmela Rita, CANDORE, Giuseppina, CARUSO, Calogero, Emanuele, F, Licastro, F, MONASTERO, Roberto, Porcellini, E, VASTO, Sonya, VERGA, Salvatore, Virruso, C   +10 more
core   +1 more source

Identification and characterization of single nucleotide polymorphisms in 12 chicken growth-correlated genes by denaturing high performance liquid chromatography

Genetics Selection Evolution, 2005
The genes that are part of the somatotropic axis play a crucial role in the regulation of growth and development of chickens. The identification of genetic polymorphisms in these genes will enable the scientist to evaluate the biological relevance of ...
Yang Guanfu, Zeng Hua, Ouyang Jianhua, Lei Mingming, Nie Qinghua, Zhang Xiquan   +5 more
doaj   +1 more source

Organization of the human genes for insulin‐like growth factors I and II [PDF]

FEBS Letters, 1986
Recently, we have reported the isolation of cDNAs encoding the precursors of insulin‐like growth factors I and II (IGF‐I and II) [(1983) Nature 306, 609‐611; (1985) FEBS Lett. 179, 243‐246. These cDNAs were employed as specific probes to detect and isolate the corresponding genes from human cosmid DNA libraries.
G.M. Verduijn, Marnix Jansen, F.M.A. van Schaik, Bonno N. Bouma, P. de Pagter-Holthuizen, G.J.B. van Ommen, John S. Sussenbach   +6 more
openaire   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Neurotrophic properties of leptomeninges [PDF]

, 1999
The leptomeninges, consisted of pia mater and arachnoid, cover the surface of brain parenchyma. Leptomeningeal cells produce a number of biologically active proteins, including prostaglandin-D synthase, cyclooxygenase-1, -2, insulin-like growth factor-II,
Ishikawa, Koichi, Ishizaka, Mami, Senbongi, Tomoko, Shibata, Kinuko   +3 more
core   +2 more sources