Results 111 to 120 of about 470,139 (379)
Cellular Physiology and Biochemistry, 2018 Background/Aims: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and ...
Yuanyuan Ji +5 more
doaj +1 more source
Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer
Biomolecules, 2020 Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms.
Pierluigi Scalia +3 more
doaj +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Serum Biomarkers for Hepatocellular Carcinoma (Short Review) [PDF]
, 2009 Hepatocellular carcinoma (HCC) atau kanker hati adalah salah satu dari kanker yang paling umum dan menjadi penyebab utama kematian di negara-negara Asia. HCC biasanya berkembang pada pasien dengan penyakit hati kronis dan sirosis.
Bachtiar, I. (Indra) +2 more
core
Advanced Biology, EarlyView.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Advanced Biology, EarlyView.Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez +3 more
wiley +1 more source
Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]
, 2015 BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong +4 more
core +2 more sources
Journal of Obesity, 2012 Nonalcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, metabolic syndrome, obesity, type 2 diabetes, and dyslipidaemia.
Said O. Muhidin +4 more
doaj +1 more source
How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
doaj +1 more source
Advanced Biology, EarlyView.The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali +5 more
wiley +1 more source