Results 251 to 260 of about 411,574 (298)

Immunoreactive insulin-like growth factor II in urine

Acta Endocrinologica, 1990
Abstract. Insulin-like growth factor II and insulin-like growth factor binding protein-1 were identified and quantified in the urine of 23 healthy subjects between 17 and 76 years of age. IGF-II was measured after separation by gel chromatography at low pH and compared with IGF-I levels in the same samples, whereas IGF binding protein-1 was measured in
W, Zumkeller, K, Hall
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Chemical synthesis of insulin‐like growth factor II

International Journal of Peptide and Protein Research, 1985
Human insulin‐like growth factor II (IGF‐II) with 67 amino acids and three disulfide bridges has been synthesized by the solid‐phase method. The synthetic hormone is shown to be homogeneous in high performance liquid chromatography (HPLC), high performance partition chromatography (HPPC), and chromatofocusing.
D, Yamashiro, C H, Li
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Insulin-Like Growth Factor II in Hepatocellular Carcinoma

Biomarkers in Medicine, 2007
Hepatocellular carcinoma is one of the most common malignant human tumors. Hepatocarcinogenesis is a multistep process with a multifactorial etiology. Chronic hepatitis B and hepatitis C virus infection, alcohol drinking and cirrhosis of any etiology are the major risk factors for hepatocellular carcinoma.
Jeng-Eing, Jeng, Lea-Yea, Chuang, Wang-Lung, Chuang, Jan-Gowth, Chang, Jung-Fa, Tsai   +4 more
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Identification of receptors for insulin-like growth factor II in two insulin-like growth factor II producing cell lines

Biochemical and Biophysical Research Communications, 1986
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
P D, Lee, D, Hodges, R L, Hintz, J H, Wyche, R G, Rosenfeld   +4 more
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Variable accumulation of insulin-like growth factor II in mouse tissues deficient in insulin-like growth factor II receptor

The International Journal of Biochemistry & Cell Biology, 1999
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
C M, Nolan, M A, Lawlor
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Insulin-Like Growth Factor-II: Possible Local Growth Factor in Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1990
Pheochromocytomas, neural crest tumors, express an abundance of insulin-like growth factor-II (IGF-II). To assess further the potential for IGF-II to play an autocrine role for these tumors, we measured 1) IGF-II content by RRA in 7 pheochromocytomas and peripheral blood in these patients, 2) IGF-II receptors by Western analysis, and 3) characterized ...
M C, Gelato, J, Vassalotti
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Insulin-like growth factor II and nonsuppressible insulin-like activity levels in newborns

American Journal of Obstetrics and Gynecology, 1990
We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. Our results obtained by use of one-way analysis of variance showed that the insulin-like growth factor II and ...
N A, Samaan, P N, Schultz, F K, Pham
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Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland

Journal of Dairy Research, 1999
The mammary gland is an example of a tissue of epidermal origin that depends for the development of its characteristic morphology on underlying mesenchymal cells. The interaction between mesenchyme and epithelium appears to be mediated by polypetide growth factors.
Forsyth, Isabel A., Gabai, Gianfranco, Morgan, Geoff   +2 more
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Insulin-like growth factor-II as a prognostic factor in pulmonary adenocarcinoma

Journal of Surgical Oncology, 1996
We stained resected specimens from 117 patients with pulmonary adenocarcinoma for insulin-like growth factor-II (IGF-II) by the avidin-biotin-peroxidase (ABC) method and evaluated the usefulness of IGF-II as a prognostic factor. The patients were classified into the IGF-II (+) groups showing staining of 1% or more cancer cells (60 patients) and the IGF-
I, Takanami, T, Imamuma, T, Hashizume, K, Kikuchi, Y, Yamamoto, T, Yamamoto, S, Kodaira   +6 more
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Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

Experimental Cell Research, 1995
The human neuroblastoma line, SK-N-SH, has been subcloned into SH-SY5Y, a neuroblast N cell line, and SH-EP, an epithelial Schwann S cell line. We have previously shown that SH-SY5Y neuroblastoma cells produce insulin-like growth factor II (IGF-II), which acts by an autocrine mechanism to stimulate cell growth.
Leventhal, P S, Randolph, A E, Vesbit, T E, Schenone, A, Windebank, A, Feldman, E L   +5 more
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