Results 251 to 260 of about 17,983,166 (291)
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Insulin-like growth factor II in the rat choroid plexus
Molecular Brain Research, 1988In situ hybridization histochemistry has been used to demonstrate the expression of the mRNA for insulin-like growth factor II (IGF-II) in the adult rat choroid plexus. IGF-II mRNA was found in the choroid plexus cells by using two different probes specific for different parts of IGF-II sequence.
Y, Ichimiya +3 more
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Metabolic clearance of insulin-like growth factor-II in sheep
Journal of Endocrinology, 1989ABSTRACT The metabolic clearance of ovine insulin-like growth factor-II (IGF-II) was examined in sheep using 131I-labelled IGF-II. Following i.v. administration the tracer was distributed in a volume similar to that of the vascular space (58-5 ±3.3 ml/kg; mean ± s.e.m., n = 5) and demonstrated a triphasic pattern of clearance.
S C, Hodgkinson +4 more
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Insulin-like growth factors I and II of nonmammalian sera
General and Comparative Endocrinology, 1985We have compared the insulin-like growth factors (IGFs) of a number of mammalian and nonmammalian vertebrate sera. Sera were subjected to acid gel filtration through G-75 Sephadex and separate binding protein and free IGF fractions were pooled. The IGF pools were subjected to flatbed isoelectric focusing and the concentration of IGF I in the fractions ...
W H, Daughaday +4 more
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Insulin-like growth factor II induces apoptosis in osteoblasts
Bone, 2004The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine orange-ethidium bromide staining.
Gloria A, Gronowicz +3 more
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Insulin-like growth factor II (IGF-II).
The international journal of biochemistry & cell biology, 1998Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I.
S D, O'Dell, I N, Day
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Calcified Tissue International, 1990
We investigated the expression of c-fos in mouse osteoblast-like cultures treated with insulin-like growth factor (IGF)-I and IGF-II. The IGFs are present in bone, are produced by osteoblast-like cells in culture, and stimulate osteoblast cell proliferation. Quiescent, subconfluent cultures of the clonal osteoblast-like mouse calvarial cell line, MC3T3-
H L, Merriman +5 more
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We investigated the expression of c-fos in mouse osteoblast-like cultures treated with insulin-like growth factor (IGF)-I and IGF-II. The IGFs are present in bone, are produced by osteoblast-like cells in culture, and stimulate osteoblast cell proliferation. Quiescent, subconfluent cultures of the clonal osteoblast-like mouse calvarial cell line, MC3T3-
H L, Merriman +5 more
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Acta Endocrinologica, 1988
Abstract. Binding of labelled IGF-I and IGF-II was studied to bovine, ovine and human placental cell membranes. The data show a preponderance of type I receptors in human placental membranes, and of type II receptors in ovine placental membranes, confirming reported data.
S, van Buul-Offers +2 more
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Abstract. Binding of labelled IGF-I and IGF-II was studied to bovine, ovine and human placental cell membranes. The data show a preponderance of type I receptors in human placental membranes, and of type II receptors in ovine placental membranes, confirming reported data.
S, van Buul-Offers +2 more
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Purification and characterization of insulin-like growth factor-II receptors
1989Publisher Summary This chapter discusses the purification and characterization of insulin-like growth factor-II (IGF-II) receptors. Successful purifications of IGF-II receptor to date have all employed IGF-II-agarose affinity chromatography. This technique has the advantage of being highly specific for the IGF-II receptor, resulting in high yields of
C D, Scott, R C, Baxter
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Acta Endocrinologica, 1989
Abstract. IGF-I and IGF-II are peptides with mitogenic properties. In this study mRNA for IGF-I and IGF-II was analysed in rat uterine tissue after different endocrine manipulations and the possibility of an estrogenic regulation of IGF expression was investigated. Both IGF-I and IGF-II mRNA were present in uterine tissue.
G, Norstedt, A, Levinovitz, H, Eriksson
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Abstract. IGF-I and IGF-II are peptides with mitogenic properties. In this study mRNA for IGF-I and IGF-II was analysed in rat uterine tissue after different endocrine manipulations and the possibility of an estrogenic regulation of IGF expression was investigated. Both IGF-I and IGF-II mRNA were present in uterine tissue.
G, Norstedt, A, Levinovitz, H, Eriksson
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The molecular and cellular biology of insulin-like growth factor II
Progress in Growth Factor Research, 1992Insulin-like growth factor II (IGF-II) is a 67 amino acid polypeptide that belongs to the family of insulin-like peptides. The IGF-II gene is coupled to the insulin gene and paternally imprinted. Multiple IGF-II mRNAs with identical coding regions and 3' untranslated regions (UTRs) but different 5' UTRs are generated from 3 promoters.
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