Results 261 to 270 of about 411,574 (298)

Insulin-Like Growth Factor-II and Insulin-Like Growth Factor-Binding Proteins in Bovine Cystic Ovarian Disease

Journal of Comparative Pathology, 2010
Cystic ovarian disease (COD) is one of the most common reproductive disorders of cattle and is considered to have multifactorial aetiology. An accepted hypothesis involves neuroendocrinological dysfunction of the hypothalamic-pituitary-gonadal axis; however, the role of growth factors in COD has not been extensively investigated.
F, Rey, F M, Rodríguez, N R, Salvetti, M M, Palomar, C G, Barbeito, N S, Alfaro, H H, Ortega   +6 more
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Insulin-like growth factor II in the rat choroid plexus

Molecular Brain Research, 1988
In situ hybridization histochemistry has been used to demonstrate the expression of the mRNA for insulin-like growth factor II (IGF-II) in the adult rat choroid plexus. IGF-II mRNA was found in the choroid plexus cells by using two different probes specific for different parts of IGF-II sequence.
Y, Ichimiya, P C, Emson, A J, Northrop, R S, Gilmour   +3 more
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Insulin-Like Growth Factor-II

1994
A 67 amino acid peptide, structurally similar to IGF-I (somatomedin C), but having greater insulin-like activity, and less growth promoting activity. Both IGF-I and IGF-II share structural similarities with proinsulin.
openaire   +1 more source

Insulin-Like Growth Factor-II Receptors

1990
In the past few years there has been an explosive increase in interest in peptides of the insulin-like growth factor (IGF) family. This follows a period of over two decades, dating back to the discovery of “somatomedins,” as the IGFs were originally known, in the late 1950s.
Robert C. Baxter, Carolyn D. Scott
openaire   +1 more source

Metabolic clearance of insulin-like growth factor-II in sheep

Journal of Endocrinology, 1989
ABSTRACT The metabolic clearance of ovine insulin-like growth factor-II (IGF-II) was examined in sheep using 131I-labelled IGF-II. Following i.v. administration the tracer was distributed in a volume similar to that of the vascular space (58-5 ±3.3 ml/kg; mean ± s.e.m., n = 5) and demonstrated a triphasic pattern of clearance.
S C, Hodgkinson, S R, Davis, L G, Moore, H V, Henderson, P D, Gluckman   +4 more
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Insulin-like growth factors I and II of nonmammalian sera

General and Comparative Endocrinology, 1985
We have compared the insulin-like growth factors (IGFs) of a number of mammalian and nonmammalian vertebrate sera. Sera were subjected to acid gel filtration through G-75 Sephadex and separate binding protein and free IGF fractions were pooled. The IGF pools were subjected to flatbed isoelectric focusing and the concentration of IGF I in the fractions ...
W H, Daughaday, M, Kapadia, C E, Yanow, K, Fabrick, I K, Mariz   +4 more
openaire   +2 more sources

Insulin-like growth factor II induces apoptosis in osteoblasts

Bone, 2004
The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine orange-ethidium bromide staining.
Gloria A, Gronowicz, Mary-Beth, McCarthy, Hai, Zhang, Wenjian, Zhang   +3 more
openaire   +2 more sources

Insulin-like growth factor II (IGF-II).

The international journal of biochemistry & cell biology, 1998
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I.
S D, O'Dell, I N, Day
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Insulin-like growth factor-I and insulin-like growth factor-II induce c-fos in mouse osteoblastic cells

Calcified Tissue International, 1990
We investigated the expression of c-fos in mouse osteoblast-like cultures treated with insulin-like growth factor (IGF)-I and IGF-II. The IGFs are present in bone, are produced by osteoblast-like cells in culture, and stimulate osteoblast cell proliferation. Quiescent, subconfluent cultures of the clonal osteoblast-like mouse calvarial cell line, MC3T3-
H L, Merriman, D, La Tour, T A, Linkhart, S, Mohan, D J, Baylink, D D, Strong   +5 more
openaire   +2 more sources

The bovine placenta: a specific radioreceptor assay for both insulin-like growth factor I and insulin-like growth factor II

Acta Endocrinologica, 1988
Abstract. Binding of labelled IGF-I and IGF-II was studied to bovine, ovine and human placental cell membranes. The data show a preponderance of type I receptors in human placental membranes, and of type II receptors in ovine placental membranes, confirming reported data.
S, van Buul-Offers, C M, Hoogerbrugge, T L, de Poorter   +2 more
openaire   +2 more sources