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Purification and characterization of insulin-like growth factor-II receptors
1989Publisher Summary This chapter discusses the purification and characterization of insulin-like growth factor-II (IGF-II) receptors. Successful purifications of IGF-II receptor to date have all employed IGF-II-agarose affinity chromatography. This technique has the advantage of being highly specific for the IGF-II receptor, resulting in high yields of
C D, Scott, R C, Baxter
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Acta Endocrinologica, 1989
Abstract. IGF-I and IGF-II are peptides with mitogenic properties. In this study mRNA for IGF-I and IGF-II was analysed in rat uterine tissue after different endocrine manipulations and the possibility of an estrogenic regulation of IGF expression was investigated. Both IGF-I and IGF-II mRNA were present in uterine tissue.
G, Norstedt, A, Levinovitz, H, Eriksson
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Abstract. IGF-I and IGF-II are peptides with mitogenic properties. In this study mRNA for IGF-I and IGF-II was analysed in rat uterine tissue after different endocrine manipulations and the possibility of an estrogenic regulation of IGF expression was investigated. Both IGF-I and IGF-II mRNA were present in uterine tissue.
G, Norstedt, A, Levinovitz, H, Eriksson
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The molecular and cellular biology of insulin-like growth factor II
Progress in Growth Factor Research, 1992Insulin-like growth factor II (IGF-II) is a 67 amino acid polypeptide that belongs to the family of insulin-like peptides. The IGF-II gene is coupled to the insulin gene and paternally imprinted. Multiple IGF-II mRNAs with identical coding regions and 3' untranslated regions (UTRs) but different 5' UTRs are generated from 3 promoters.
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Expression of insulin‐like growth factor II mRNA in hepatocellular carcinoma
Journal of Gastroenterology and Hepatology, 1998ABSTRACTInsulin‐like growth factor II (IGF‐II) is a mitogenic polypeptide closely related to insulin. Its gene has complex regulation of transcription, resulting in multiple mRNA initiated by different promoters. To study its role in hepatocarcinogenesis, we examined the expression of IGF‐II mRNA in hepatocellular carcinomas (HCC) and correlated it ...
Lee, JMF, Ng, M, Srivastava, G, Ng, IOL
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Insulin-like growth factor-II imprinting in cancer
The Lancet, 2002Anthony E, Reeve +3 more
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Insulin‐like growth factors I and II
European Journal of Biochemistry, 1990openaire +3 more sources
Receptors for insulin-like growth factors I and II
1989The somatomedins (SMs) comprise a family of growth hormone (GH)-dependent, insulin-like peptides with metabolic and mitogenic actions in a wide variety of cell lines (Phillips and Vassilopoulou-Sellin 1980). While their precise role in the regulation of cellular replication remains uncertain, a growing body of data supports the hypothesis that these ...
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