Results 321 to 330 of about 463,657 (378)

Variable accumulation of insulin-like growth factor II in mouse tissues deficient in insulin-like growth factor II receptor

The International Journal of Biochemistry & Cell Biology, 1999
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
Margaret A. Lawlor, Catherine M. Nolan
openaire   +3 more sources

Identification of receptors for insulin-like growth factor II in two insulin-like growth factor II producing cell lines

Biochemical and Biophysical Research Communications, 1986
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
D. Hodges, R. G. Rosenfeld, R. L. Hintz, J. H. Wyche, Phillip D.K. Lee   +4 more
openaire   +3 more sources

Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.

New England Journal of Medicine, 1988
We describe a case of recurrent hypoglycemia apparently caused by secretion of insulin-like growth factor II (IGF-II) by a leiomyosarcoma. A 67-year-old woman presented with recurrent severe hypoglycemia and a large mass in the thorax.
W. Daughaday, M. Emanuele, M. Brooks, A. L. Barbato, Milan Kapadia, P. Rotwein   +5 more
semanticscholar   +1 more source

Insulin-Like Growth Factor-II Receptors

1990
In the past few years there has been an explosive increase in interest in peptides of the insulin-like growth factor (IGF) family. This follows a period of over two decades, dating back to the discovery of “somatomedins,” as the IGFs were originally known, in the late 1950s.
Carolyn D. Scott, Robert C. Baxter
openaire   +2 more sources

Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors.

Journal of Clinical Endocrinology and Metabolism, 1994
Little is known about the pathophysiology of sporadic adrenocortical tumors in adults. Because loss of heterozygosity at the 11p15 locus has been described in childhood tumors, particularly, in adrenocortical tumors, associated with the Beckwith ...
C. Gicquel, X. Bertagna, H. Schneid, M. Francillard-Leblond, J. Luton, F. Girard, Y. Bouc   +6 more
semanticscholar   +1 more source

Insulin-Like Growth Factor-II and Insulin-Like Growth Factor-Binding Proteins in Bovine Cystic Ovarian Disease

Journal of Comparative Pathology, 2010
Cystic ovarian disease (COD) is one of the most common reproductive disorders of cattle and is considered to have multifactorial aetiology. An accepted hypothesis involves neuroendocrinological dysfunction of the hypothalamic-pituitary-gonadal axis; however, the role of growth factors in COD has not been extensively investigated.
Martin M. Palomar, Florencia Rey, Florencia Rey, Natalia Soledad Alfaro, Claudio Gustavo Barbeito, Claudio Gustavo Barbeito, Natalia Raquel Salvetti, Natalia Raquel Salvetti, Fernanda Mariel Rodríguez, Hugo Hector Ortega, Hugo Hector Ortega   +10 more
openaire   +3 more sources

Insulin-like growth factor II and nonsuppressible insulin-like activity levels in newborns

American Journal of Obstetrics and Gynecology, 1990
We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. Our results obtained by use of one-way analysis of variance showed that the insulin-like growth factor II and ...
Naguib A. Samaan, Pamela N. Schultz, Frank K. Pham   +2 more
openaire   +3 more sources

Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

Science, 1992
The Wilms tumor suppressor gene wt1 encodes a zinc finger DNA binding protein, WT1, that functions as a transcriptional repressor. The fetal mitogen insulin-like growth factor II (IGF-II) is overexpressed in Wilms tumors and may have autocrine effects in
I. Drummond, S. Madden, P. Rohwer-Nutter, G. Bell, V. Sukhatme, F. Rauscher   +5 more
semanticscholar   +1 more source

Insulin-like growth factor-II as a prognostic factor in pulmonary adenocarcinoma

Journal of Surgical Oncology, 1996
We stained resected specimens from 117 patients with pulmonary adenocarcinoma for insulin-like growth factor-II (IGF-II) by the avidin-biotin-peroxidase (ABC) method and evaluated the usefulness of IGF-II as a prognostic factor. The patients were classified into the IGF-II (+) groups showing staining of 1% or more cancer cells (60 patients) and the IGF-
Toshinori Hashizume, Tatsuya Yamamoto, Yasuki Yamamoto, Susumu Kodaira, Iwao Takanami, Tetsuo Imamuma, Keiichi Kikuchi   +6 more
openaire   +3 more sources

A single receptor binds both insulin-like growth factor II and mannose-6-phosphate.

Science, 1988
Amino acid sequences deduced from rat complementary DNA clones encoding the insulin-like growth factor II (IGF-II) receptor closely resemble those of the bovine cation-independent mannose-6-phosphate receptor (Man-6-P receptorCI), suggesting they are ...
R. Macdonald, S. Pfeffer, L. Coussens, M. Tepper, Carol M. Brocklebank, J. Mole, Jacqueline K. Anderson, E. Chen, M. Czech, A. Ullrich   +9 more
semanticscholar   +1 more source