Results 331 to 340 of about 463,657 (378)

Evidence for two species of insulin-like growth factor II (IGF II and "big" IGF II) in human spinal fluid.

Endocrinology, 1982
Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts.
G. Haselbacher, R. Humbel
semanticscholar   +1 more source

Insulin-like growth factor II in the rat choroid plexus

Molecular Brain Research, 1988
In situ hybridization histochemistry has been used to demonstrate the expression of the mRNA for insulin-like growth factor II (IGF-II) in the adult rat choroid plexus. IGF-II mRNA was found in the choroid plexus cells by using two different probes specific for different parts of IGF-II sequence.
Andrew J. Northrop, Yosuke Ichimiya, R. Stewart Gilmour, Piers C. Emson   +3 more
openaire   +3 more sources

Insulin-like growth factors I and II of nonmammalian sera

General and Comparative Endocrinology, 1985
We have compared the insulin-like growth factors (IGFs) of a number of mammalian and nonmammalian vertebrate sera. Sera were subjected to acid gel filtration through G-75 Sephadex and separate binding protein and free IGF fractions were pooled. The IGF pools were subjected to flatbed isoelectric focusing and the concentration of IGF I in the fractions ...
Ida K. Mariz, William H. Daughaday, Kurt Fabrick, Caryl E. Yanow, Milan Kapadia   +4 more
openaire   +3 more sources

Metabolic clearance of insulin-like growth factor-II in sheep

Journal of Endocrinology, 1989
ABSTRACT The metabolic clearance of ovine insulin-like growth factor-II (IGF-II) was examined in sheep using 131I-labelled IGF-II. Following i.v. administration the tracer was distributed in a volume similar to that of the vascular space (58-5 ±3.3 ml/kg; mean ± s.e.m., n = 5) and demonstrated a triphasic pattern of clearance.
Peter D. Gluckman, Stephen R. Davis, S. C. Hodgkinson, Harold V. Henderson, L. G. Moore   +4 more
openaire   +3 more sources

Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland

Journal of Dairy Research, 1999
The mammary gland is an example of a tissue of epidermal origin that depends for the development of its characteristic morphology on underlying mesenchymal cells. The interaction between mesenchyme and epithelium appears to be mediated by polypetide growth factors.
Forsyth, Isabel A., Gabai, Gianfranco, Morgan, Geoff   +2 more
openaire   +5 more sources

[24] Radioligand assays for insulin-like growth factor II

1987
Publisher Summary This chapter focuses on the methods of measurement of insulin-like growth factor II (IGF-II). There is assay evidence that chicken serum and turtle serum contain IGF-I and IGF-II, but toad and trout serum seem to contain only IGF-I-like peptide.
openaire   +3 more sources

Insulin-like growth factor II induces apoptosis in osteoblasts

Bone, 2004
The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine orange-ethidium bromide staining.
Hai Zhang, Mary Beth McCarthy, Gloria Gronowicz, Wenjian Zhang   +3 more
openaire   +3 more sources

Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

Experimental Cell Research, 1995
The human neuroblastoma line, SK-N-SH, has been subcloned into SH-SY5Y, a neuroblast N cell line, and SH-EP, an epithelial Schwann S cell line. We have previously shown that SH-SY5Y neuroblastoma cells produce insulin-like growth factor II (IGF-II), which acts by an autocrine mechanism to stimulate cell growth.
Leventhal, P S, Randolph, A E, Vesbit, T E, Schenone, A, Windebank, A, Feldman, E L   +5 more
openaire   +4 more sources

Differential expression of insulin-like growth factor II in human meningiomas

Neurosurgery, 1991
Two glioma tumor lines and brain tumor specimens from 10 patients were analyzed to determine genic expression of insulin-like growth factor II. Messenger ribonucleic acid encoding insulin-like growth factor II was found to be expressed in significant amounts in two of two meningiomas but not in any of the gliomas.
Terry Lichtor, Mark E. Gurney, M. A. Kurpakus   +2 more
openaire   +3 more sources

The molecular and cellular biology of insulin-like growth factor II

Progress in Growth Factor Research, 1992
Insulin-like growth factor II (IGF-II) is a 67 amino acid polypeptide that belongs to the family of insulin-like peptides. The IGF-II gene is coupled to the insulin gene and paternally imprinted. Multiple IGF-II mRNAs with identical coding regions and 3' untranslated regions (UTRs) but different 5' UTRs are generated from 3 promoters.
openaire   +3 more sources