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Purification and characterization of insulin-like growth factor-II receptors
1989Publisher Summary This chapter discusses the purification and characterization of insulin-like growth factor-II (IGF-II) receptors. Successful purifications of IGF-II receptor to date have all employed IGF-II-agarose affinity chromatography. This technique has the advantage of being highly specific for the IGF-II receptor, resulting in high yields of
Robert C. Baxter, Carolyn D. Scott
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Expression of insulin‐like growth factor II mRNA in hepatocellular carcinoma
Journal of Gastroenterology and Hepatology, 1998ABSTRACTInsulin‐like growth factor II (IGF‐II) is a mitogenic polypeptide closely related to insulin. Its gene has complex regulation of transcription, resulting in multiple mRNA initiated by different promoters. To study its role in hepatocarcinogenesis, we examined the expression of IGF‐II mRNA in hepatocellular carcinomas (HCC) and correlated it ...
Lee, JMF, Ng, M, Srivastava, G, Ng, IOL
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Receptors for insulin-like growth factors I and II
1989The somatomedins (SMs) comprise a family of growth hormone (GH)-dependent, insulin-like peptides with metabolic and mitogenic actions in a wide variety of cell lines (Phillips and Vassilopoulou-Sellin 1980). While their precise role in the regulation of cellular replication remains uncertain, a growing body of data supports the hypothesis that these ...
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Parental imprinting of the mouse insulin-like growth factor II gene
Cell, 1991T. Dechiara +2 more
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Review Insulin-Like Growth Factors I and II
1990Insulin-like growth factors (IGF) I and II are two peptides which have been isolated originally from a Cohn fraction of human serum [1]. The designation IGF has been proposed [2] to stress the fact that they showed mitogenic effects at concentrations in the nanomolar range in vitro, that they also exhibited insulin-like effects in adipose and muscle ...
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Insulin-like growth factor-II imprinting in cancer
The Lancet, 2002David M.O. Becroft +6 more
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Insulin-Like Growth Factor II Gene Expression
1992Publisher Summary Several methods have been described for binding protein removal that are adequate for neural tissue. Although it is desirable to have high recovery rates and efficient separation of hormone and protein, other factors such as time, number of samples to be processed, and origin of tissue to be examined all must be weighed to arrive at
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Insulin-like growth factor II receptor as a multifunctional binding protein
Nature, 1987D. Morgan +6 more
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Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
Nature, 1993O. Ogawa +7 more
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