Results 51 to 60 of about 411,574 (298)

Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen‐induced liver failure [PDF]

, 1993
Sixty‐two beagle dogs were given three doses of acetaminophen over a period of 24 hr in a fulminant liver failure model that is 70% lethal in 72 hr.
Abecassis, Bontempo, Bravo, Clavien, Farivar, Fausto, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Fujiwara, Fujiwara, Gohda, Gove, Harrison, Kawakita, Kirsch, Lewis, Lewis, Lewis, Lindroos, McKeown, Michalopoulos, Milandri, Minuk, Miyachi, Miyazaki, Nakamura, Okuda, Panella, Saunders, Starzl, Starzl, Starzl, Starzl, Takahashi, Tsubouchi, Van Assendelfp, Zarnegar   +40 more
core   +1 more source

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R [PDF]

, 2016
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II ...
Abell, Andrew D, Brimble, Margaret Anne, Cottam Jones, Jade M, Forbes, Briony E, Harris, Paul William Richard, Scanlon, Denis B   +5 more
core   +1 more source

Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II [PDF]

Biochemical Journal, 1992
We investigated the binding properties of the type I insulin-like growth factor (IGF) receptor expressed in NIH-3T3 fibroblasts transfected with a human type I receptor cDNA. Cell surface receptors bound IGF-I with KD = 1 nM as predicted. Although recent studies have suggested that IGF-I and IGF-II bind to type I receptors with near-equal affinity, the
E L, Germain-Lee, M, Janicot, R, Lammers, A, Ullrich, S J, Casella   +4 more
openaire   +2 more sources

Understanding IGF-II Action through Insights into Receptor Binding and Activation

Cells, 2020
The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and ...
Andrew J. Blyth, Nicholas S. Kirk, Briony E. Forbes   +2 more
doaj   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]

, 2012
Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
David Epstein, Franco Folli, Hassan Nakhai, James Young, Julia Herold, Luxian Zhou, Michael Khan, Stella Pelengaris, Sylvie Abouna, Tim Wilhelm Nattkemper   +9 more
core   +3 more sources

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.

PLoS ONE, 2019
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett, Eileen Hsu, Justin M Thomas, Joseph M Pilewski, Carol Feghali-Bostwick   +4 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Funk, B., Hansmann, A., Kessler, U., Kiess, W., Kolb, H. J.   +5 more
core   +1 more source

Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. II. Body Composition [PDF]

, 2007
The current study is a comprehensive genome analysis to detect QTL affecting metabolic traits in chickens. Two unique F2 crosses generated from a commercial broiler male line and 2 genetically distinct inbred lines (Leghorn and Fayoumi) were used in the ...
Ashwell, C. M., Evock-Clover, C. M., Lamont, Susan, Lamont, Susan, McMurtry, J. P., Zhou, H.   +5 more
core   +5 more sources

Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats

Journal of Translational Medicine, 2011
Background Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rats reducing oxidative damage in ...
Castilla-Cortazar Inma, Guerra Lucia, Puche Juan E, Sierra Inma, Garcia-Fernandez Maria   +4 more
doaj   +1 more source

Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula [PDF]

, 1991
Completely diverting portacaval shunt (Eck's fistula) in dogs causes hepatocyte atrophy, disruption of hepatocyte organelles, fatty infiltration and lowgrade hyperplasia. The effect of hepatic growth regulatory substances on these changes was assessed by
Azzarone, A, Barone, M, Carrieri, G, Foglieni, CS, Francavilla, A, Michalopoulos, GK, Porter, K, Starzl, TE, Trejo, J, Zeng, QH   +9 more
core   +1 more source