Results 61 to 70 of about 19,025,094 (297)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease. [PDF]

PLoS ONE, 2015
Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to ...
Eirini Kalliolia, Edina Silajdžić, Rajasree Nambron, Seán J Costelloe, Nicholas G Martin, Nathan R Hill, Chris Frost, Hilary C Watt, Peter Hindmarsh, Maria Björkqvist, Thomas T Warner   +10 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Retroperitoneal Doege–Potter syndrome with intraoperative blood glucose monitoring

IJU Case Reports
Background Doege–Potter syndrome, characterized by solitary fibrous tumors and non‐islet cell tumor hypoglycemia, is rare. Here, we report a case of Doege–Potter syndrome in which retroperitoneal tumor resection was performed with continuous ...
Hirotaka Nagasaka, Takahisa Suzuki, Takuya Kondo, Mitsuyuki Koizumi, Hideyuki Terao, Yuko Murohashi, Yoichiro Okubo, Tomoyuki Yokose, Takeshi Kishida   +8 more
doaj   +1 more source

Cell-free synthesis of rat insulin-like growth factor II [PDF]

Diabetes, 1982
Total RNA extracted from a rat liver cell line (BRL 3A) that synthesizes rat insulin-like growth factor II (IGF-II) was translated in a reticulocyte lysate cell-free system. Incubation of the translation products with antisera to mature rat IGF-II (Mr 8700) selectively immunoprecipitated a Mr 21,600 protein.
ACQUAVIVA, ANGELA MARIA, BRUNI C. B., NISSLEY S. P., AND RECHLER M. M.   +3 more
openaire   +3 more sources

Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [PDF]

, 2013
Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
Brosseau, C, Colston, KW, G. Pirianov, K. W. Colston, C. Brosseau, Pirianov, G   +5 more
core   +1 more source

Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss

, 2021
OBJECTIVES: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL). (2) To test the effect of local administration of IGF-1 in patients with ototoxicity.
Varun Jitendra Dave, Kshitij Shah, Manish Prajapati, Joshi, Anagha, Shah, Kshitij, Renuka Bradoo, Dave, Varun Jitendra, Prajapati, Manish, Bradoo, Renuka, Anagha Joshi   +9 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Insulin-like growth factors I and II in evaluation of growth retardation

The Journal of Pediatrics, 1986
Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level less than 7 ng/ml), 44 normal short children, and 197 children with normal height were assayed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II.
R G, Rosenfeld, D M, Wilson, P D, Lee, R L, Hintz   +3 more
openaire   +2 more sources