Results 1 to 10 of about 14,458,916 (288)

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. [PDF]

Structure, 2022
Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These hybrid receptors display ligand binding and signaling properties that differ from those of the homodimeric receptors.
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC.   +8 more
europepmc   +8 more sources

Immunohistochemical analysis of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue and endometrium

Acta Obstetricia et Gynecologica Scandinavica, 1997
Background. The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue, and to compare ...
Shiuh Y. Chang, Yat‐Sen Ho
doaj   +4 more sources

Insulin-like growth factor receptor signaling in physiology and disease [PDF]

Signal Transduction and Targeted Therapy
The insulin-like growth factor (IGF) signaling pathway plays a pivotal role in regulating a myriad of cellular and physiological processes, including cell proliferation, differentiation, and the maintenance of redox homeostasis.
Muhammad Dilawar, Anoosha Malik, Junguang Liao, Panpan Shen, Ziyi Huang, Pengxiang Zhang, Jiaqi Wang, Nenghua Zhang, Muhammad Farrukh Nisar, Guiqian Chen   +9 more
doaj   +2 more sources

How ligand binds to the type 1 insulin-like growth factor receptor [PDF]

Nature Communications, 2018
The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like
Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence   +9 more
doaj   +2 more sources

Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor [PDF]

Stem Cells International, 2019
As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat ...
Doaa Aboalola, Victor K. M. Han
doaj   +2 more sources

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.

Structure, 2020
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC.   +9 more
europepmc   +2 more sources

Regulation and function of insulin and insulin-like growth factor receptor signalling. [PDF]

Nat Rev Mol Cell Biol
Choi E, Duan C, Bai XC.
europepmc   +2 more sources

Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease

Neural Regeneration Research, 2023
Skin-derived precursor Schwann cells have been reported to play a protective role in the central nervous system. The neuroprotective effects of skin-derived precursor Schwann cells may be attributable to the release of growth factors that nourish host ...
Hai-Ying Zhang, Yong-Cheng Jiang, Jun-Rui Li, Jia-Nan Yan, Xin-Jue Wang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu   +7 more
doaj   +1 more source

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

Cell Death and Disease, 2022
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala   +6 more
doaj   +1 more source

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

Frontiers in Endocrinology, 2023
IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation.
Stefania Stella, Stefania Stella, Michele Massimino, Michele Massimino, Livia Manzella, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Silvia Rita Vitale, Federica Martorana, Federica Martorana, Paolo Vigneri, Paolo Vigneri, Paolo Vigneri   +13 more
doaj   +1 more source