Results 81 to 90 of about 14,458,916 (288)

Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas

, 2014
A greater understanding of brain metastases is imperative for developing novel therapeutic strategies. Our previous study showed that insulin-like growth factor (IGF) signaling pathway was activated in brain-tropic cancer cells.
Wu, Pei-Fang;Huang, Wen-Chang;Yang, James Chih-Hsin;Lu, Yen-Shen;Shih, Jin-Yuan;Wu, Shang-Gin;Lin, Ching-Hung;Cheng, Ann-Lii, 楊志新 ;盧彥伸 ;鄭安理 ;吳尚俊 ;施金元 ;林璟宏   +1 more
core   +1 more source

Insulin-like growth factor and growth hormone receptor in nephrotic rats

American Journal of Physiology-Endocrinology and Metabolism, 1994
In an attempt to elucidate the mechanism of growth retardation in the nephrotic syndrome, specific serum and hepatic growth factors were measured in Sprague-Dawley rats in which nephrotic syndrome was produced by administration of puromycin (1.5 mg.100 g body wt-1.day-1) for 12 days. On the 13th day, the results of these nephrotic animals were compared
Thabet, M. A., Challa, A., Chan, W., Liu, F., Hintz, R. L., Chan, J. C.   +5 more
openaire   +3 more sources

Supplementary Data from Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

, 2009
Supplementary Data from Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and ...
Laetitia Fartoux (14908962), Friedhelm Bladt (14977990), Chantal Housset (775823), Aurore Baron (14977981), Corinne Venot (14977987), Olivier Rosmorduc (76342), Marie-José Blivet-Van Eggelpoël (14977984), Christèle Desbois-Mouthon (14899755)   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ligand-mediated Endocytosis and Trafficking of the Insulin-like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function

Frontiers in Endocrinology, 2014
The insulin-like growth factor (IGF-I) system and its two major receptors, the IGF-IR and IR, plays a central role in a variety of physiological cellular processes including growth, differentiation, motility and glucose homeostasis.
Alaide eMorcavallo, Alaide eMorcavallo, Manuela eStefanello, Manuela eStefanello, Renato V Iozzo, Antonino eBelfiore, Andrea eMorrione   +6 more
doaj   +1 more source

Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries

, 2019
Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal effects of high-fat diet compared to low-fat diet in mice on insulin receptor, insulin-like growth
Slaaby, R, Kearney, MT, Mughal, RS, Worm, J, Yuldasheva, N, Cubbon, R, Schiødt, M, Makava, N, Bridge, K, Hvid, H, Skromna, A, Buza, I, Klitgaard-Povlsen, G, Skytte-Olsen, G   +13 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

BMC Bioinformatics, 2001
Background Leucine-rich repeats are one of the more common modules found in proteins. The leucine-rich repeat consensus motif is LxxLxLxxNxLxxLxxLxxLxx- where the first 11–12 residues are highly conserved and the remainder of the repeat can vary in size ...
Ward Colin W, Garrett Thomas PJ
doaj   +1 more source

A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5 ' UTR located within intron 11 [PDF]

, 2009
Background: The leukocyte common antigen related receptor (LAR) protein has been shown to modulate the signal transduction of a number of different growth factors, including insulin and insulin-like growth factor 1.
Salter, AM, Welham, SJ, Simon JM Welham, Clark, AJ, Adrian JL Clark, Andrew M Salter   +5 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source