Results 101 to 110 of about 14,458,916 (288)

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

iScience
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is ...
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward   +12 more
doaj   +1 more source

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

A radioligand binding assay for the insulin-like growth factor 2 receptor.

PLoS ONE, 2020
Insulin-like growth factors 2 and 1 (IGF2 and IGF1) and insulin are closely related hormones that are responsible for the regulation of metabolic homeostasis, development and growth of the organism.
Pavlo Potalitsyn, Irena Selicharová, Kryštof Sršeň, Jelena Radosavljević, Aleš Marek, Kateřina Nováková, Jiří Jiráček, Lenka Žáková   +7 more
doaj   +1 more source

Supplementary Table S1 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

, 2008
Supplementary Table S1 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...
An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523)   +25 more
core   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1. [PDF]

Mol Cell Biol, 2023
Clark NK, Harris MT, Dahl WB, Knotts Z, Marr MT.   +4 more
europepmc   +1 more source

Supplementary Fig. S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

, 2008
Supplementary Fig. S3 from Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose ...
An Song (10874351), Wei-Ching Liang (1593526), Yonglei Shang (14909469), Kenji Kozuka (5684108), Jean-Philippe Stephan (40079), Yan Wu (70890), Suzie J. Scales (14895671), Congfen Li (11890795), Zora Modrusan (37892), Sang Hoon Lee (211083), Siao Ping Tsai (1958665), Sarajane Ross (14881149), Klaus Hoeflich (15040823), Alexander Vanderbilt (15040820), Gail Phillips (2372092), Jennifer Batson (3719461), Mark R. Lackner (14886740), Avi Ashkenazi (30123), Simon Williams (155614), Zhijun Tang (9643426), Jiping Zha (4917034), Jihong Yang (585406), Yifan Mao (11903012), Christine Tan (15040817), Klara Totpal (14899089), Janet Tien (14894523)   +25 more
core   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Redox Biology, 2017
Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing.
E. Martín-Montañez, C. Millon, F. Boraldi, F. Garcia-Guirado, C. Pedraza, E. Lara, L.J. Santin, J. Pavia, M. Garcia-Fernandez   +8 more
doaj   +1 more source