Results 121 to 130 of about 815 (149)

Structural and Computational Insights into the Angiotensin II Type 1 Receptor: Advances in Antagonist Design and Implications for Hypertension Therapy (2020-2024). [PDF]

Biomolecules
Chatzipieris FP, Petsas E, Lambrinidis G, Matsoukas JM, Mavromoustakos T.   +4 more
europepmc   +1 more source

Modification of adipogenesis and oxidative stress by quercetin: positive or negative impact on adipose tissue metabolism of obese diabetic Zucker rats? [PDF]

J Physiol Biochem
Kršková K, Dobrócsyová V, Ferenczyová K, Hricovíniová J, Kaločayová B, Duľová U, Bozorgnia M, Barteková M, Zorad Š.   +8 more
europepmc   +1 more source

Hemorphins, atypical endogenous opiate peptides, in sickle cell disease and their association with pain. [PDF]

Pain
Tan Y, Kashyap Y, De La Toba E, Croslow SW, Gill M, Guo X, Ilktach G, Davy E, Molokie R, Wang ZJ, Sweedler JV.   +10 more
europepmc   +1 more source

ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights. [PDF]

J Med Chem
Fougiaxis V, He B, Khan T, Vatinel R, Koutroumpa NM, Afantitis A, Lesire L, Sierocki P, Deprez B, Deprez-Poulain R.   +9 more
europepmc   +1 more source

The role of protein palmitoylation in disease pathogenesis and therapeutic innovation. [PDF]

Ann Med
Lin X, Xing J, Jia K, Liu S, Liu Y, Gu Y, Guo K, Yi J.   +7 more
europepmc   +1 more source

Effects of ligands or substrate of insulin‐regulated aminopeptidase (IRAP) on trophoblast invasion

Journal of Peptide Science, 2008
AbstractInsulin‐regulated aminopeptidase (IRAP) activity increases during placentation and in the invasive tumor cell of trophoblast suggesting a role for this peptidase in the invasiveness of normal and malignant trophoblast. To investigate this hypothesis, we studied the effects of substrate (OT) and inhibitors (angiotensin peptides and LVV‐H7) of ...
Marie Cohen, Siew Yeen Chai, Paul Bischof   +2 more
exaly   +6 more sources

Angiotensin IV displays only low affinity for native insulin‐regulated aminopeptidase (IRAP)

Fundamental & Clinical Pharmacology, 2011
AbstractRadioligand binding studies revealed that Ang IV binds to insulin‐regulated aminopeptidase (IRAP)/’AT4 receptors’ with high affinity. Yet, as these experiments were routinely carried out in the presence of chelators, only the catalytic zinc‐depleted apo‐form of IRAP was labelled.
Demaegdt, Heidi, De Backer, Jean-Paul, Lukaszuk, Aneta, Tóth, Géza, Szemenyei, E, Tourwe, Dirk, Vauquelin, Georges   +6 more
core   +5 more sources

Small potent ligands to the insulin‐regulated aminopeptidase (IRAP)/AT₄ receptor

Journal of Peptide Science, 2007
AbstractAngiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays. Several of the ligands displayed high affinities to the insulin‐regulated aminopeptidase (IRAP)/AT4 receptor.
Axen, A., Andersson, H, Lindeberg, G, Ronnholm, H, Kortesmaa, J, Demaegdt, Heidi, Vauquelin, Georges, Karlen, A., Hallberg, M.   +8 more
openaire   +4 more sources