Results 191 to 200 of about 131,691 (303)

Characterization of Human Pituitary Adenomas in Cell Cultures by Light And Electron Microscopic Morphology And Immunolabeling

, 2005
The morphology and hormone production of pituitary adenoma cell cultures were compared in order to highlight their characteristic in vitro features. Cell suspensions were prepared from 494 surgical specimens.
Bácsy, Ernő, Hegedűs, Balázs, Slowik, Felicia, Bálint, Katalin, Pásztor, Emil, Kerekes, Edit, Fazekas, Ilona   +6 more
core  

Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis

Advanced Science, EarlyView.
ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu, Chang‐geng Xu, Xiao‐wei Hu, Run‐run Shan, Jia‐nan Wang, Xiang‐yu Li, Yu‐qing Wang, Yu‐hang Dong, Shen‐Zhuo‐Fan Huang, Shuai Sun, Tian Zhao, Ya‐Xin Ru, Xiao‐yu Shen, Rui Hou, Jian‐min You, Fei Zhang, Chao Li, Jie Wei, Chao Hou, Zhi‐juan Wang, Dan‐feng Zhang, Juan Jin, Jia‐gen Wen, Yu‐jie Liu, Ming‐ming Liu, Xiao‐ming Meng, Wei Wang   +26 more
wiley   +1 more source

Optical Nanoscopy of Cytokine-Induced Structural Alterations of the Endoplasmic Reticulum and Golgi Apparatus in Insulin-Secreting Cells. [PDF]

Int J Mol Sci
Pugliese LA, De Lorenzi V, Tesi M, Marchetti P, Cardarelli F.   +4 more
europepmc   +1 more source

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells. [PDF]

Cell Commun Signal, 2019
Santo-Domingo J, Galindo AN, Cominetti O, De Marchi U, Cutillas P, Dayon L, Wiederkehr A.   +6 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Insulin-like growth factor-II : cellular effects through different receptors

, 1998
Insulin-like growth factor-II (IGF-II) and IGF-I are single-chain polypeptides structurally homologous to proinsulin and share similarities with insulin in functional characteristics.
Qimin Zhang (17692601)
core  

Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity. [PDF]

Acta Diabetol
Hyder A, Sheta B, Eissa M, Schrezenmeir J.   +3 more
europepmc   +1 more source

Trace amine-associated receptor 1 (TAAR1) promotes anti-diabetic signaling in insulin-secreting cells. [PDF]

J Biol Chem, 2019
Michael ES, Covic L, Kuliopulos A.
europepmc   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells. [PDF]

Mol Biol Cell
Amos C, Kiessling V, Kreutzberger AJB, Schenk NA, Mohan R, Nyenhuis S, Doyle CA, Wang HY, Levental K, Levental I, Anantharam A, Tamm LK.   +11 more
europepmc   +1 more source