Results 211 to 220 of about 98,089 (330)

Functional Enhancement of Electrofusion‐derived BRIN‐BD11 Insulin‐secreting Cells After Implantation into Diabetic Mice [PDF]

, 2000
Emma L. Davies, Yasser H.A. Abdel‐Wahab, Peter R. Flatt, Clifford J. Bailey   +3 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells. [PDF]

Mol Biol Cell
Amos C, Kiessling V, Kreutzberger AJB, Schenk NA, Mohan R, Nyenhuis S, Doyle CA, Wang HY, Levental K, Levental I, Anantharam A, Tamm LK.   +11 more
europepmc   +1 more source

Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells [PDF]

, 2013
Georgia Pennarossa, S. Maffei, Marino Campagnol, Letizia Tarantini, F. Gandolfi, Tiziana A. L. Brevini   +5 more
openalex   +1 more source

Immunoreactive inhibin in human follicular fluid in an ovarian hyperstimulation proramme for in vitro fertilisation: correlations and different forms [PDF]

, 1993
Lechner, K., Mehltretter, G., Müller, O. A., Reichardt, Bärbel, Rjosk, H. K., Schopohl, J.   +5 more
core   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Docosahexanoic Acid Attenuates Palmitate-Induced Apoptosis by Autophagy Upregulation via GPR120/mTOR Axis in Insulin-Secreting Cells. [PDF]

Endocrinol Metab (Seoul)
Hong SW, Lee J, Moon SJ, Kwon H, Park SE, Rhee EJ, Lee WY.   +6 more
europepmc   +1 more source

Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents. [PDF]

PLoS One, 2018
Southard SM, Kotipatruni RP, Rust WL.
europepmc   +1 more source

Diagnosis and treatment of ACTH-producing pituitary tumors [PDF]

, 1978
Baur, X., Bayer, J. M., Fahlbusch, R., Fahlbusch, R., Madler, M., Marguth, F., Müller, O. A., Scriba, Peter Christian, Uhlig, C., Werder, Klaus von   +9 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source