Results 221 to 230 of about 57,117 (262)
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Calmodulin in various insulin secreting cell types
Journal of Endocrinological Investigation, 1985The involvement of the Ca2+ binding protein, calmodulin, in the regulation of insulin release was studied. Calmodulin was measured in isolated rat islets, rat insulinoma cells, the insulin secreting cell line (RINm5F) and in islets isolated from normal and diabetic Chinese hamsters. Total content of calmodulin was determined by a radioimmunoassay using
D, Janjic, C B, Wollheim, A E, Renold
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Inhibition of K-Channels in Insulin Secreting Cells
1986The major physiological stimulus for insulin secretion from pancreatic β-cells is an elevation of the plasma glucose concentration. The initial effect is to evoke membrane depolarization4 followed by a cyclical pattern of electrical activity consisting of slow waves of depolarization with action potential-like spikes.9,12 Tracer flux studies have ...
O H, Petersen, I, Findlay, M J, Dunne
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Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells
Journal of Proteome Research, 2013Cell-cell interactions are of fundamental importance for cellular function. In islets of Langerhans, which control blood glucose levels by secreting insulin in response to the blood glucose concentration, the secretory response of intact islets is higher than that of insulin-producing beta-cells not arranged in the islet architecture. The objective was
Satagopam, Venkata P. +7 more
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Insulin‐Secreting Islet‐Cell Tumours of the Pancreas
Australian and New Zealand Journal of Surgery, 1967Some current thoughts on the subject of insulin‐secreting islet‐cell tumours of the pancreas are presented, and a typical case is reported. On the diagnostic side, mention is made of newer aids to diagnosis in the form of tolbutamide and leucine tests and possibly insulin assays.
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Some aspects of the morphology of insulin-secreting cells
Acta Histochemica, 1976By using a spectrum of microscopical techniques such as thin sectioning, autoradiography, cytochemistry and freeze-etching, it is possible to unravel the main cytological events associated with synthesis, intracellular transport, storage and discharge of the hormone insulin by B-cell of the islet of Langerhans.
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Cytotoxic action of methylglyoxal on insulin-secreting cells.
Biochemical pharmacology, 2001Methylglyoxal is a spontaneous product of glucose metabolism which is known to have cytotoxic actions and to be present in raised concentrations in hyperglycaemia. It could therefore play an important role in glucose toxicity. We have investigated the cytotoxic effects of methylglyoxal on insulin-secreting cells, which are particularly sensitive to ...
Sheader, Elizabeth A. +2 more
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β-Cell Lipases and Insulin Secretion
Diabetes, 2006Lipids have been implicated in β-cell stimulus-secretion coupling. Thus, lipases in β-cells would be required to generate coupling factors from intracellular lipids. Indeed, we found that glucose stimulates lipolysis in rodent islets and clonal β-cells.
Malin Fex +5 more
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Islet‐cell‐to‐cell communication as basis for normal insulin secretion
Diabetes, Obesity and Metabolism, 2007The emergence of pancreatic islets has necessitated the development of a signalling system for the intra‐ and inter‐islet coordination of β cells. With evolution, this system has evolved into a complex regulatory network of partially cross‐talking pathways, whereby individual cells sense the state of activity of their neighbours and, accordingly ...
Bavamian S +7 more
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Elusive proximal signals of beta-cells for insulin secretion
Diabetes, 1990The β-cell is unique because its major agonists, i.e., insulin secretagogues, undergo metabolism instead of interacting with a receptor. This perspectives presents the hypothesis that the first part of a metabolic signal of a secretagogue is specific to the secretagogue and the β-cell and can be envisioned as proximal.
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Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells
1993The cytoplasmic free Ca2+ concentration([Ca2+]i) has a fundamental role in the β-cell stimulus-secretion coupling and is regulated by a sophisticated interplay between nutrients, hormones and neurotransmitters. Metabolism of glucose and other nutrients leads to ATP generation, closure of ATP-regulated K+-channels, depolarization, opening of voltage ...
Per-Olof Berggren +12 more
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