Generation of insulin‐secreting cells from human embryonic stem cells [PDF]
Development, Growth & Differentiation, 2006 A growth factor‐mediated selection method was used to obtained insulin‐secreting cells from human embryonic stem cells (hESC; Royan H1). Our resultant cells were positive for dithizone, a zinc‐chelating agent known to selectively stain pancreatic β cells and immunoreactive for antibodies against insulin, glucagon, and C‐peptide.
Hossein, Baharvand +3 more
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Recent Advances in Obesity-induced Inflammation and Insulin Resistance.
Frontiers in Endocrinology, 2013 It has been demonstrated in rodents and humans that chronic inflammation characterized by macrophage infiltration occurs mainly in adipose tissue or liver during obesity, in which activation of immune cells is closely associated with insulin sensitivity.
Sanshiro eTateya +3 more
doaj +1 more source
Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]
, 2012 Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J. +5 more
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Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins [PDF]
Journal of Biological Chemistry, 2003 Diabetes is associated with significant changes in plasma concentrations of lipoproteins. We tested the hypothesis that lipoproteins modulate the function and survival of insulin-secreting cells. We first detected the presence of several receptors that participate in the binding and processing of plasma lipoproteins and confirmed the internalization of
Roehrich, Marc-Estienne Maurice +10 more
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ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]
, 1989 The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core
Oleanolic acid enhances insulin secretion in pancreatic β‐cells [PDF]
FEBS Letters, 2008 We investigated the effect of oleanolic acid, a plant‐derived triterpenoid, on insulin secretion and content in pancreatic β‐cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS‐1 832/13 cells and enhanced acute glucose‐stimulated insulin secretion in isolated rat islets ...
Teodoro, T. +5 more
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JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis [PDF]
, 2018 Aims/hypothesis: In insulin-secreting cells, activation of the c-Jun NH2-terminal kinase (JNK) pathway triggers apoptosis. Whereas JNK1 and JNK2 are ubiquitously produced, JNK3 has been described exclusively in neurons.
Abdelli, S. +7 more
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ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
Nature Communications, 2017 Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and ...
Zaniar Ghazizadeh +12 more
doaj +1 more source
Molecular Mechanisms of Secreting Vesicle Biogenesis and Secretion in Chronic Degenerative Diseases [PDF]
, 2012 Regulated trafficking and secretion of insulin by the β cell of the endocrine pancreas is critical to maintain our body energy homeostasis. Disruption of these processes typically leads to hyperglycemia and the complications of diabetes.
Qiao, Xinxian
core
Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells [PDF]
, 2016 open5noMost endocrine cells secrete hormones as a result of Ca(2+)-regulated exocytosis, i.e., fusion of the membranes of hormone-containing secretory granules with the cell membrane, which allows the hormone molecules to escape to the extracellular ...
Cortese, Giuliana +4 more
core +1 more source