Results 111 to 120 of about 2,129,772 (314)

Recommendation for Forensic Identification Guidelines on Insulin Overdoes

Fayixue Zazhi
Insulin is an important protein hormone that participates in multiple metabolic pathways. Biosynthetic insulin has been widely used in the treatment of type 1 and type 2 diabetes.
YUAN Yu-hao, YU Zhong-hao, ZHANG Jia-xin, MA Long-da, ZHAO Shu-quan, LIU Ning-guo, WU Rong-qi, ZHANG Biao, LIAO Xin-biao, CHEN Xin, HE Guang-long, ZHOU Yi-wu   +11 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Relationship of MicroRNAs with Transposable Elements in the Type 1 Diabetes Development

Архивъ внутренней медицины
The review article describes the involvement of epigenetic factors in type 1 diabetes mellitus (T1DM) etiopathogenesis. The disease is characterized by changes in expression of microRNAs that affect the transcription of genes involved in autoimmune ...
R. N. Mustafin
doaj   +1 more source

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

The use of intuitive AF-based modelling for the understanding of activation and signalling through insulin-like receptors

Frontiers in Endocrinology
The understanding of the conformational events occurring through the Insulin-like Receptors (ILRs) upon binding of their cognate hormones is very advanced, thanks to multidisciplinary efforts and breakthroughs, from molecular/cell biology to structural ...
Andrzej M. Brzozowski, Talha Shafi, Olga V. Moroz, Pierre De Meyts   +3 more
doaj   +1 more source

Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin

Drug Delivery, 2018
Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor protein (TCTP-PTD 13, MIIFRALISHKK) was ...
Hae-Duck Bae, Joohyun Lee, Kyu-Yeon Jun, Youngjoo Kwon, Kyunglim Lee   +4 more
doaj   +1 more source

Impact of Pre-Processed Chickpea Flour Incorporation into “Mankoushe” on Appetite Hormones and Scores

Foods, 2018
Recently, there has been an increasing interest in integrating pulse flours into pastries and baked products to improve their nutritional and health benefits.
Sahar Dandachy, Hiba Mawlawi, Marwan Chedid, Carla El-Mallah, Omar Obeid   +4 more
doaj   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications

Life
Type 2 diabetes (T2D) is a prevalent metabolic disorder characterized by persistent hyperglycemia, hyperinsulinemia, and long-term cardiovascular complications.
Katherine Deck, Christoph Mora, Shuoqiu Deng, Pamela Rogers, Tonya Rafferty, Philip T. Palade, Shengyu Mu, Yunmeng Liu   +7 more
doaj   +1 more source

Effect of FSH and insulin on lipogenesis in cultures of Sertoli cells from immature rats

Brazilian Journal of Medical and Biological Research, 1997
Follicle-stimulating hormone (FSH) and insulin regulate glycide metabolism in Sertoli cells, thus stimulating lactate production. These stimulatory effects of FSH and insulin do not require protein synthesis, suggesting a modulation of enzyme activity ...
F.C.R. Guma, M Wagner, L.H. Martini, E.A. Bernard   +3 more
doaj   +1 more source