Results 91 to 100 of about 2,026,798 (359)

Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes - A randomized clinical trial [PDF]

, 2004
OBJECTIVE—Insulin detemir is a soluble long-acting basal insulin analog designed to overcome the limitations of conventional basal insulin formulations.
Bartley, Paul, Russell-Jones, David, Lang, Hanne, Landin-Olsson, M., Lang, H., Hanaire-Broutin, Helene, Draeger, Eberhard, Hanaire-Broutin, H., Abrams, Pascale, Landin-Olsson, Mona,, Russell-Jones, D., Bartley, Paul Anthony, Draeger, E., Hylleberg, Birgitte, Bartley, P., Hylleberg, B., Heeg, J.E., Home, Philip, Lund University., Home, P., Heeg, Jan-Evert, Landin-Olsson, Mona   +21 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study [PDF]

, 2013
Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with ...
Rita Chadarevian, Eastell, R. (Richard), Richard J Ross, Richard Eastell (153287), Chadarevian, Rita, Debono, M., Newell-Price, John, Rita Chadarevian (399995), Richard J. Ross (399996), Richard Eastell, Randeva, Harpal S., Chadarevian, R., John Newell-Price (399997), Newell-Price, J., Ross, R.J., Miguel Debono (399994), Ross, Richard J. M., Miguel Debono, John Newell-Price, Eastell, R.   +19 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Sustained expression of hemopexin in an animal model of sickle cell anemia

Blood Vessels, Thrombosis & Hemostasis
: Sickle cell disease is a condition characterized by vaso-occlusive episodes and sustained hemolysis, leading to a chronic inflammatory state. Several studies have shown that the release of heme to the extracellular space due to hemolysis contributes to
Franciele De Lima, Carla Roberta Peachazepi De Moraes, Ivanio Teixeira Borba-Junior, Heloísa Balan Assalin, Mario José Abdalla Saad, Fernando Ferreira Costa, Erich V. De Paula   +6 more
doaj   +1 more source

Designing an oral insulin delivery system based on milk exosomes for managing diabetes: in vitro and in vivo investigation [PDF]

Nanomedicine Journal
Objective(s): Oral drug administration is a noninvasive, painless, and convenient strategy that eliminates the need for routine injection routes. In recent years, milk-derived exosomes (Mexos) have gained tremendous interest as vehicles for oral drug ...
Sadegh Dehghani, Reza Zolfaghari, Seyed Mohamaad Taghdisi, Khalil Abnous, Mona Alibolandi, Mohammad Ramezani   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

Nature Communications
The insulin receptor entrains tissue growth and metabolism to nutritional conditions. Complete loss of function in humans leads to extreme insulin resistance and infantile mortality, while loss of 80-90% function permits longevity of decades.
Vahid Aslanzadeh, Gemma V. Brierley, Rupa Kumar, Hasan Çubuk, Corinne Vigouroux, Kenneth A. Matreyek, Grzegorz Kudla, Robert K. Semple   +7 more
doaj   +1 more source

Molecular evolution and functional characterization of Drosophila insulin-like peptides [PDF]

, 2010
Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and ...
Gronke, S, Clarke, DF, Linda Partridge, Partridge, Linda, Andrews, T., Partridge, L., Broughton, S, Broughton, Susan, David-Francis Clarke, T Daniel Andrews, Grönke, S., Andrews, T Daniel, Grönke, Sebastian, Broughton, S., Partridge, L, Sebastian Grönke, Andrews, TD, Susan Broughton, Andrews, T. Daniel, Clarke , D., Clarke, David-Francis   +20 more
core   +1 more source