Results 101 to 110 of about 2,026,798 (359)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

High-Fat Diet : Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse [PDF]

, 2010
Background: Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation.
Michael M Chi, Scott Magness, Jobin, Christian, Christian Jobin, Jobin Christian, Scull Brooks P., Brooks P. Scull, Lund Pauline K., Chi Michael M., Magness Scott, Shengli Ding, Pauline K Lund, Scull, Brooks P., Nicole M. J. Schwerbrock, Brooks P Scull, Nicole M J Schwerbrock, Chi, Michael M., Ding Shengli, Magness, Scott, Rigby Rachael, Schwerbrock, Nicole M. J., Schwerbrock Nicole M. J., Rigby, Rachael, Ding, Shengli, Lund, Pauline K., Michael M. Chi, Pauline K. Lund, Rachael Rigby   +27 more
core   +1 more source

Insulin action and resistance in obesity and type 2 diabetes

Nature Medicine, 2017
Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose tissue. However, conflicting evidence indicates a lack of knowledge of
M. Czech
semanticscholar   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial

Journal of Diabetes Research
Conclusion: The circuit training program implemented in women newly diagnosed with insulin resistance significantly increased their serum IL-6 and not their IL-10, FGF21, and irisin levels.
Joanna Karolkiewicz, Monika Krzywicka, Monika Szulińska, Katarzyna Musialik, Dominka Musiałowska, Jacek Zieliński, Agnieszka Bilska, Marzena Ratajczak   +7 more
doaj   +1 more source

Incidence of insulin-treated diabetes in Australia 2000-2011 [PDF]

, 2014
Australia\u27s rate of incidence of insulin-treated diabetes has remained stable over the last decade, with between 10 and 12 new cases per 100,000 population per year.

core  

Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise [PDF]

, 2012
Gold OAAs most sport drinks contain some form of non-nutritive sweetener (e.g. aspartame), and with the variation in blood glucose regulation and insulin secretion reportedly associated with aspartame, a further understanding of the effects on insulin ...
Mellor, D., Keith Howell, Howell, K., Towlson, C., Rebecca Vince, Mellor, Duane, Peart, Daniel, Bray, J., Towlson, Christopher, James Bray, Siegler, Jason C. (R16634), Howell, Keith, Jason Siegler, Duane Mellor, Siegler, Jason, Siegler, J., Daniel Peart, Vince, Rebecca, Stephen Atkin, Vince, R., Peart, D., Atkin, Stephen, Bray, James W., Chris Towlson, Bray, James, Atkin, S., Towlson, Chris   +26 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Utilizing the Glucose and Insulin Response Shape of an Oral Glucose Tolerance Test to Predict Dysglycemia in Children with Overweight and Obesity, Ages 8–18 Years

Diabetology
Common dysglycemia measurements including fasting plasma glucose (FPG), oral glucose tolerance test (OGTT)-derived 2 h plasma glucose, and hemoglobin A1c (HbA1c) have limitations for children. Dynamic OGTT glucose and insulin responses may better reflect
Timothy J. Renier, Htun Ja Mai, Zheshi Zheng, Mary Ellen Vajravelu, Emily Hirschfeld, Diane Gilbert-Diamond, Joyce M. Lee, Jennifer L. Meijer   +7 more
doaj   +1 more source